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<!--Section Begins--><br> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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<b>PRAZINON</b><b><sup> </sup></b><b><sup>®</sup></b><b> plus </b> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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tablet for dogs |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<div align="left"> |
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<p style="text-align: left;"> |
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<b><i>Composition</i></b> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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1 tablet contains: |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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50 mg of praziquantel |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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144 mg of pyrantel pamoate |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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150 mg of febantel |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Adjuvants: lactose, maize starch, copolividon, sodium lauryl sulphate, cellulose microcrystalline, highly dispersible silicium dioxide, hydrogenated vegetable oil, talc and magnesium stearate. |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<div align="left"> |
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<p style="text-align: left;"> |
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<b><i>Action</i></b> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Three active ingredients that do not interfere in their action but rather act individually ensure a broad-spectrum anthelmintic action of the tablets. |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Praziquantel acts cestocidally, against mature and immature tapeworms (cestodes). After oral administration it is rapidly and almost completely resorbed from the intestines, metabolised in the liver and excreted by urine and bile. Cestocidal action is based on the ability to damage the cuticle of tapeworms and cause spastic muscular paralysis. Praziquantel acts against the parasites in duodenal mucosa and against juvenile stages of echinococci buried in the crypts of Lieberkühn. Several seconds after its interaction with phospholipids and proteins of tapeworms, their cuticle is damaged and Ca<b><sup>++</sup></b> ions penetrate the parasite's cells causing contractions of the whole strobila. The parasites' resistance to digestive enzymes is lost, they die and are being digested. For this reason the host's feces rarely contain the whole body, scolex or proglottides the parasite. |
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</p> |
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</div> |
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<div align="justify"> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Pyrantel pamoate acts against many roundworms (nematodes) where it inhibits neuromuscular transmission of impulses, thus causing spastic paralysis of their muscles. Peristalsis of the host's intestines helps excrete dead parasites. |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Febantel is probenzimidazole which is in the liver of dogs transformed into active metabolites of oxfendazole and fenbendazole. In the enterocytes and cuticle of the parasites they bind to the structural protein turbulin, preventing polymerisation of microtubuli indispensable in the transport system of the resorption cells and, thus, leading to autolysis of nematodes. Pyrantel and febantel do not act synergistically. |
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</p> |
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</div> |
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<div align="justify"> |
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</p> |
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</div> |
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<div align="left"> |
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<p style="text-align: left;"> |
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<b><i>Indications</i></b> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Control of infestation of adult dogs and puppets with nematodes (roundworms) and cestodes (tapeworms), in particular: |
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</p> |
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</div> |
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<ul> |
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<li> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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nematodes: <i>Toxocara canis; Toxascaris leonina; Uncinaria stenocephala; Ancylostoma caninum</i> and <i>Trichuris vulpis</i>; |
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</p> |
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</div> |
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<li> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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cestodes: <i>Echinococcus granulosus; Echinococcus multilocularis; Dipylidium caninum; Taenia hydatigena; Taenia pisiformis; Taenia taeniaeformis; Taenia serialis, Taenia multiceps; Taenia ovis; Taenia cervi; Mesocestoides spp.</i> and <i>Joyeuxiella spp.</i> |
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</p> |
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</div> |
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</ul> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<div align="left"> |
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<p style="text-align: left;"> |
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<b><i>Contraindications</i></b> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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First 40 days of gravity. |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<div align="left"> |
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<p style="text-align: left;"> |
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<b><i>Administration and dosage</i></b> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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The tablets are given alone or mixed with food (chopped meat, cheese, etc.), preferably before the meal. It is not necessary to restrict the animals from food beforehand. |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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The dose is 1 tablet/10 kg of b.w. once daily (i. e. 5 mg of praziquantel, 14.4 mg of pyrantel pamoate and 15 mg of febantel per kg of b.w.). |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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For regular dehelminthisation it is recommended to repeat the treatment every 3 months. In severe infestation re-institute the drug after 14 days. |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Puppets and small dogs: |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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0.5-2 kg of b.w. 1/4 tablet |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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2 - 5 kg of b.w. 1/2 tablet |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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|
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5-10 kg of b.w. 1 tablet |
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|
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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|
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</p> |
739 |
</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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|
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Medium-size dogs: |
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</p> |
758 |
</div> |
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769 |
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770 |
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<div align="justify"> |
772 |
<p style="text-align: justify;"> |
773 |
|
774 |
10-20 kg of b.w. 2 tablets |
775 |
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</p> |
777 |
</div> |
778 |
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789 |
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<div align="justify"> |
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<p style="text-align: justify;"> |
792 |
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793 |
20-30 kg of b.w. 3 tablets |
794 |
|
795 |
</p> |
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</div> |
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799 |
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800 |
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<div align="justify"> |
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<p style="text-align: justify;"> |
811 |
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813 |
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</p> |
815 |
</div> |
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820 |
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826 |
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827 |
|
828 |
<div align="justify"> |
829 |
<p style="text-align: justify;"> |
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|
831 |
Large dogs: |
832 |
|
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</p> |
834 |
</div> |
835 |
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836 |
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838 |
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839 |
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840 |
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844 |
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846 |
|
847 |
<div align="justify"> |
848 |
<p style="text-align: justify;"> |
849 |
|
850 |
30-40 kg of b.w. 4 tablets |
851 |
|
852 |
</p> |
853 |
</div> |
854 |
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855 |
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856 |
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857 |
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858 |
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860 |
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861 |
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863 |
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864 |
|
865 |
|
866 |
<div align="justify"> |
867 |
<p style="text-align: justify;"> |
868 |
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869 |
|
870 |
|
871 |
</p> |
872 |
</div> |
873 |
|
874 |
|
875 |
|
876 |
|
877 |
|
878 |
|
879 |
|
880 |
|
881 |
|
882 |
|
883 |
|
884 |
|
885 |
<div align="justify"> |
886 |
<p style="text-align: justify;"> |
887 |
|
888 |
Given that puppets may be infested by tapeworms only after 3<sup>rd</sup> week of life, Prazinon<sup>®</sup> plus may be given after this period if mixed infestation with roundworms and tapeworms is established. It is recommended to perform regular dehelminthisation of dogs prior to vaccination. |
889 |
|
890 |
</p> |
891 |
</div> |
892 |
|
893 |
|
894 |
|
895 |
|
896 |
|
897 |
|
898 |
|
899 |
|
900 |
|
901 |
|
902 |
|
903 |
|
904 |
<div align="justify"> |
905 |
<p style="text-align: justify;"> |
906 |
|
907 |
|
908 |
|
909 |
</p> |
910 |
</div> |
911 |
|
912 |
|
913 |
|
914 |
|
915 |
|
916 |
|
917 |
|
918 |
|
919 |
|
920 |
|
921 |
|
922 |
|
923 |
<div align="left"> |
924 |
<p style="text-align: left;"> |
925 |
|
926 |
<b><i>Side effects</i></b> |
927 |
|
928 |
</p> |
929 |
</div> |
930 |
|
931 |
|
932 |
|
933 |
|
934 |
|
935 |
|
936 |
|
937 |
|
938 |
|
939 |
|
940 |
|
941 |
|
942 |
<div align="justify"> |
943 |
<p style="text-align: justify;"> |
944 |
|
945 |
Unknown. |
946 |
|
947 |
</p> |
948 |
</div> |
949 |
|
950 |
|
951 |
|
952 |
|
953 |
|
954 |
|
955 |
|
956 |
|
957 |
|
958 |
|
959 |
|
960 |
|
961 |
<div align="justify"> |
962 |
<p style="text-align: justify;"> |
963 |
|
964 |
|
965 |
|
966 |
</p> |
967 |
</div> |
968 |
|
969 |
|
970 |
|
971 |
|
972 |
|
973 |
|
974 |
|
975 |
|
976 |
|
977 |
|
978 |
|
979 |
|
980 |
<div align="left"> |
981 |
<p style="text-align: left;"> |
982 |
|
983 |
<b><i>Warnings and precautions</i></b> |
984 |
|
985 |
</p> |
986 |
</div> |
987 |
|
988 |
|
989 |
|
990 |
|
991 |
|
992 |
|
993 |
|
994 |
|
995 |
|
996 |
|
997 |
|
998 |
|
999 |
<div align="justify"> |
1000 |
<p style="text-align: justify;"> |
1001 |
|
1002 |
Care should be exercised when administering preparations containing pyrantel to very weak animals. Praziquantel does not act on the eggs of tapeworms. Therefore, over first 2 days after the treatment feces of the treated animals should be disposed of in a safe way (landfill or combustion). |
1003 |
|
1004 |
</p> |
1005 |
</div> |
1006 |
|
1007 |
|
1008 |
|
1009 |
|
1010 |
|
1011 |
|
1012 |
|
1013 |
|
1014 |
|
1015 |
|
1016 |
|
1017 |
|
1018 |
<div align="justify"> |
1019 |
<p style="text-align: justify;"> |
1020 |
|
1021 |
|
1022 |
|
1023 |
</p> |
1024 |
</div> |
1025 |
|
1026 |
|
1027 |
|
1028 |
|
1029 |
|
1030 |
|
1031 |
|
1032 |
|
1033 |
|
1034 |
|
1035 |
|
1036 |
|
1037 |
<div align="justify"> |
1038 |
<p style="text-align: justify;"> |
1039 |
|
1040 |
Given that fleas serve as intermediate hosts to <i>D. caninum</i> tapeworm, dehelminthisation programme should include concomitant extermination of fleas. |
1041 |
|
1042 |
</p> |
1043 |
</div> |
1044 |
|
1045 |
|
1046 |
|
1047 |
|
1048 |
|
1049 |
|
1050 |
|
1051 |
|
1052 |
|
1053 |
|
1054 |
|
1055 |
|
1056 |
<div align="justify"> |
1057 |
<p style="text-align: justify;"> |
1058 |
|
1059 |
|
1060 |
|
1061 |
</p> |
1062 |
</div> |
1063 |
|
1064 |
|
1065 |
|
1066 |
|
1067 |
|
1068 |
|
1069 |
|
1070 |
|
1071 |
|
1072 |
|
1073 |
|
1074 |
|
1075 |
<div align="justify"> |
1076 |
<p style="text-align: justify;"> |
1077 |
|
1078 |
Do not exceed the recommended dose, particularly when treating pregnant bitches. |
1079 |
|
1080 |
</p> |
1081 |
</div> |
1082 |
|
1083 |
|
1084 |
|
1085 |
|
1086 |
|
1087 |
|
1088 |
|
1089 |
|
1090 |
|
1091 |
|
1092 |
|
1093 |
|
1094 |
<div align="justify"> |
1095 |
<p style="text-align: justify;"> |
1096 |
|
1097 |
|
1098 |
|
1099 |
</p> |
1100 |
</div> |
1101 |
|
1102 |
|
1103 |
|
1104 |
|
1105 |
|
1106 |
|
1107 |
|
1108 |
|
1109 |
|
1110 |
|
1111 |
|
1112 |
|
1113 |
<div align="left"> |
1114 |
<p style="text-align: left;"> |
1115 |
|
1116 |
<b><i>Storage</i></b> |
1117 |
|
1118 |
</p> |
1119 |
</div> |
1120 |
|
1121 |
|
1122 |
|
1123 |
|
1124 |
|
1125 |
|
1126 |
|
1127 |
|
1128 |
|
1129 |
|
1130 |
|
1131 |
|
1132 |
<div align="justify"> |
1133 |
<p style="text-align: justify;"> |
1134 |
|
1135 |
Store at the temperature up to 25°C. Keep away from children. |
1136 |
|
1137 |
</p> |
1138 |
</div> |
1139 |
|
1140 |
|
1141 |
|
1142 |
|
1143 |
|
1144 |
|
1145 |
|
1146 |
|
1147 |
|
1148 |
|
1149 |
|
1150 |
|
1151 |
<div align="justify"> |
1152 |
<p style="text-align: justify;"> |
1153 |
|
1154 |
|
1155 |
|
1156 |
</p> |
1157 |
</div> |
1158 |
|
1159 |
|
1160 |
|
1161 |
|
1162 |
|
1163 |
|
1164 |
|
1165 |
|
1166 |
|
1167 |
|
1168 |
|
1169 |
|
1170 |
<div align="left"> |
1171 |
<p style="text-align: left;"> |
1172 |
|
1173 |
<b><i>Legal category</i></b> |
1174 |
|
1175 |
</p> |
1176 |
</div> |
1177 |
|
1178 |
|
1179 |
|
1180 |
|
1181 |
|
1182 |
|
1183 |
|
1184 |
|
1185 |
|
1186 |
|
1187 |
|
1188 |
|
1189 |
<div align="justify"> |
1190 |
<p style="text-align: justify;"> |
1191 |
|
1192 |
OTC |
1193 |
|
1194 |
</p> |
1195 |
</div> |
1196 |
|
1197 |
|
1198 |
|
1199 |
|
1200 |
|
1201 |
|
1202 |
|
1203 |
|
1204 |
|
1205 |
|
1206 |
|
1207 |
|
1208 |
<div align="justify"> |
1209 |
<p style="text-align: justify;"> |
1210 |
|
1211 |
|
1212 |
|
1213 |
</p> |
1214 |
</div> |
1215 |
|
1216 |
|
1217 |
|
1218 |
|
1219 |
|
1220 |
|
1221 |
|
1222 |
|
1223 |
|
1224 |
|
1225 |
|
1226 |
|
1227 |
<div align="left"> |
1228 |
<p style="text-align: left;"> |
1229 |
|
1230 |
<b><i>Shelf life</i></b> |
1231 |
|
1232 |
</p> |
1233 |
</div> |
1234 |
|
1235 |
|
1236 |
|
1237 |
|
1238 |
|
1239 |
|
1240 |
|
1241 |
|
1242 |
|
1243 |
|
1244 |
|
1245 |
|
1246 |
<div align="justify"> |
1247 |
<p style="text-align: justify;"> |
1248 |
|
1249 |
Denoted on the packaging. |
1250 |
|
1251 |
</p> |
1252 |
</div> |
1253 |
|
1254 |
|
1255 |
|
1256 |
|
1257 |
|
1258 |
|
1259 |
|
1260 |
|
1261 |
|
1262 |
|
1263 |
|
1264 |
|
1265 |
<div align="justify"> |
1266 |
<p style="text-align: justify;"> |
1267 |
|
1268 |
|
1269 |
|
1270 |
</p> |
1271 |
</div> |
1272 |
|
1273 |
|
1274 |
|
1275 |
|
1276 |
|
1277 |
|
1278 |
|
1279 |
|
1280 |
|
1281 |
|
1282 |
|
1283 |
|
1284 |
<div align="left"> |
1285 |
<p style="text-align: left;"> |
1286 |
|
1287 |
<b><i>Manufacturer</i></b> |
1288 |
|
1289 |
</p> |
1290 |
</div> |
1291 |
|
1292 |
|
1293 |
|
1294 |
|
1295 |
|
1296 |
|
1297 |
|
1298 |
|
1299 |
|
1300 |
|
1301 |
|
1302 |
|
1303 |
<div align="justify"> |
1304 |
<p style="text-align: justify;"> |
1305 |
|
1306 |
VETERINA Animal Health Ltd., Croatia |
1307 |
|
1308 |
</p> |
1309 |
</div> |
1310 |
|
1311 |
|
1312 |
|
1313 |
|
1314 |
|
1315 |
|
1316 |
|
1317 |
<!--Section Ends--> |
1318 |
|
1319 |
|
1320 |
|
1321 |
|
1322 |
|
1323 |
|
1324 |
|
1325 |
|