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<!--Section Begins--><br> |
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<p style="text-align: justify;"> |
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<b><i>TIAVET</i></b><b><sup>®</sup></b><b><i> P 2% </i></b> |
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<i>medicated additive</i> for swine and poultry |
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</div> |
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<b></b> |
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<b><i>Composition</i></b><b></b> |
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</p> |
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1000 g contain 20 g of tiamulin as tiamulin hydrogen fumarate. |
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<b><i>Action</i></b><b></b> |
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Tiamulin is a semi-synthetic derivative of diterpen antibiotic pleuromutilin. It has a broad antimicrobial spectrum and is very potent against mycoplasma (<i>Mycoplasma gallisepticum, M. synoviae, M. meleagridis, M. hyopneumoniae </i>and<i> M. hyorhinis</i>),<i> </i>treponema (<i>Serpulina hyodysenteriae</i>)<i>,</i> leptospira (<i>Leptospira </i>spp.), gram-positive bacteria (<i>Staphylococcus</i> sp., <i>Streptococcus</i> sp., <i>Clostridium perfringens, Listeria monocytogenes, Erysipelothrix</i> <i>insidiosa</i>, <i>Actinomyces pyogenes</i>) and gram-negative bacteria (<i>Actinobacillus </i>spp., <i>Pasteurella</i> spp., <i>Klebsiella pneumoniae, Fusobacterium necrophorum, Campylobacter coli</i>). In the sensitive organisms Tiavet<b><sup>®</sup></b> acts bacteriostatically, i. e. inhibits their protein synthesis by binding to their ribosomes and diminishing the action of peptidyl-transferase. Taken orally it is rapidly and completely resorbed, achieving therapeutic levels in blood and tissues. Tiamulin hydrogen fumarate is almost completely biodegraded, mostly excreted by bile and the rest by urine. |
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</p> |
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<b><i>Indications</i></b><b></b> |
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<i>Swine:</i> |
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Metaphylaxis and treatment of respiratory infections, e. g. enzootic pneumonia (<i>Mycoplasma hyopneumoniae</i>) and pleuropneumonia (<i>Actinobacillus pleuropneumoniae</i>), as well as of the complications secondary to respiratory infections due to <i>M. hyorhinis </i>and<i> Pasteurella</i> spp. |
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Metaphylaxis and treatment of swine dysentery (<i>Serpulina hyodysenteriae</i>). |
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<i>Poultry:</i> |
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Metaphylaxis and treatment of respiratory infections (CRD) caused by mycoplasma (<i>M. gallisepticum </i>and<i> M. synoviae)</i> and of secondary bacterial infections (<i>E. coli, Haemophilus gallinarum</i> and<i> Pasteurella</i> spp.). |
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</p> |
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<b><i>Contraindications</i></b> |
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Tamulin should not be given to swine and poultry concomitantly with ionophor antibiotics (e. g. monensin, narasin, salinomycine, maduramycine and lasalocyde) and 7 days prior to and 7 days from their administration. |
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</p> |
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Tiamulin is contraindicated in commercial layers. |
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</div> |
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<b><i>Administration and dosage</i></b> |
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</div> |
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<i>Swine:</i> |
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</p> |
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</div> |
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<p style="text-align: justify;"> |
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Dysentery and enzootic pneumonia in swine are managed with 10 kg of Tiavet<b><sup>®</sup></b>2% P /1 T of feed (200 ppm of tiamulin). Usually the treatment lasts 5 days (dysentery) to 10 days (enzootic pneumonia and actinobacillus pleuropneumoniae). |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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In metaphylaxis of dysentery and enzootic pneumonia 1.25-2.5 kg of Tiavet<b><sup>®</sup></b> 2% P are mixed with 1 T of feed (25-50 ppm of tiamulin). Level of Tiavet<b><sup>®</sup></b>2% P in feed and duration of treatment should be adjusted to the severity of disease and the breeding period, i. e. Tiavet<b><sup>®</sup></b> 2% P should be given in the clinical peak season of infection. |
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</p> |
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</div> |
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<p style="text-align: justify;"> |
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Metaphylaxis in highly risky situations allows higher doses, e. g. 5 kg of Tiavet<b><sup>®</sup></b> 2% P/1 T of feed (100 ppm of tiamulin). |
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</p> |
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</div> |
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</p> |
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</div> |
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<p style="text-align: justify;"> |
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In concurrent risk of colibacillosis and salmonellosis, Tiavet<b><sup>®</sup></b> 2% P is given with medicated additives effective against respective pathogens (e. g. Trimetosul<b><sup>®</sup></b> P or Geotrim<b><sup>®</sup></b> P) in the recommended concentration and suggested duration of treatment. |
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</p> |
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</div> |
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</p> |
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</div> |
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<i>Poultry:</i> |
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</p> |
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</div> |
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<div align="justify"> |
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In metaphylaxis of chronic respiratory disease (CRD) in chicks Tiavet<b><sup>®</sup></b> 2% P is given over their first three days of life in the dose of 12.5 kg /1 T of feed (250 ppm of tiamulin). |
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</p> |
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</div> |
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</div> |
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In the increased risk metaphylactic dose is repeated: to broilers during their fourth week of life, to the offsppring of layers on weeks 4, 9 and 20 of their life. At these times concentration of 250 ppm is given with feed over one day. |
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</p> |
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</div> |
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</p> |
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Mycoplasmal infections are treated over three consecutive days with 25 kg of Tiavet<b><sup>®</sup></b> 2% P/1 T of feed (500 ppm tiamulin). |
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</p> |
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</div> |
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</p> |
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<b><i>Side effects</i></b> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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On very rare occasions tiamulin may produce skin erythema on the stomach and genitals of swine which requires its discontinuation and washing of the animals with water to remove traces of faeces and urine. Oral administration of electrolyte solutions and antiphlogistic has shown to be of value in such instances. |
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</p> |
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</div> |
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|
827 |
<div align="justify"> |
828 |
<p style="text-align: justify;"> |
829 |
|
830 |
<b><i></i></b> |
831 |
|
832 |
</p> |
833 |
</div> |
834 |
|
835 |
|
836 |
|
837 |
|
838 |
|
839 |
|
840 |
|
841 |
|
842 |
|
843 |
|
844 |
|
845 |
|
846 |
<div align="justify"> |
847 |
<p style="text-align: justify;"> |
848 |
|
849 |
Warnings and precautions<b></b> |
850 |
|
851 |
</p> |
852 |
</div> |
853 |
|
854 |
|
855 |
|
856 |
|
857 |
|
858 |
|
859 |
|
860 |
|
861 |
|
862 |
|
863 |
|
864 |
|
865 |
<div align="justify"> |
866 |
<p style="text-align: justify;"> |
867 |
|
868 |
Tiamulin is not recommended in pregnant sows and gilts. |
869 |
|
870 |
</p> |
871 |
</div> |
872 |
|
873 |
|
874 |
|
875 |
|
876 |
|
877 |
|
878 |
|
879 |
|
880 |
|
881 |
|
882 |
|
883 |
|
884 |
<div align="justify"> |
885 |
<p style="text-align: justify;"> |
886 |
|
887 |
|
888 |
|
889 |
</p> |
890 |
</div> |
891 |
|
892 |
|
893 |
|
894 |
|
895 |
|
896 |
|
897 |
|
898 |
|
899 |
|
900 |
|
901 |
|
902 |
|
903 |
<div align="justify"> |
904 |
<p style="text-align: justify;"> |
905 |
|
906 |
Sick animals taking scarce feed should be given Tiavet<b><sup>®</sup></b> 2% P with drinking water or, preferably, parenterally. |
907 |
|
908 |
</p> |
909 |
</div> |
910 |
|
911 |
|
912 |
|
913 |
|
914 |
|
915 |
|
916 |
|
917 |
|
918 |
|
919 |
|
920 |
|
921 |
|
922 |
<div align="justify"> |
923 |
<p style="text-align: justify;"> |
924 |
|
925 |
|
926 |
|
927 |
</p> |
928 |
</div> |
929 |
|
930 |
|
931 |
|
932 |
|
933 |
|
934 |
|
935 |
|
936 |
|
937 |
|
938 |
|
939 |
|
940 |
|
941 |
<div align="justify"> |
942 |
<p style="text-align: justify;"> |
943 |
|
944 |
If after three days of treatment there is no apparent improvement, the preparation may be continued only if laboratory tests show sensitivity of the causative organism to tiamulin. |
945 |
|
946 |
</p> |
947 |
</div> |
948 |
|
949 |
|
950 |
|
951 |
|
952 |
|
953 |
|
954 |
|
955 |
|
956 |
|
957 |
|
958 |
|
959 |
|
960 |
<div align="justify"> |
961 |
<p style="text-align: justify;"> |
962 |
|
963 |
|
964 |
|
965 |
</p> |
966 |
</div> |
967 |
|
968 |
|
969 |
|
970 |
|
971 |
|
972 |
|
973 |
|
974 |
|
975 |
|
976 |
|
977 |
|
978 |
|
979 |
<div align="justify"> |
980 |
<p style="text-align: justify;"> |
981 |
|
982 |
To ensure homogeneity of mixing with complete feed, add beforehand the required volume of Tiavet<b><sup>®</sup></b> 2% P to some feed<sup> </sup>(e. g. 7-20 kg), or to one components of the complete feed (e. g. mineral additives). |
983 |
|
984 |
</p> |
985 |
</div> |
986 |
|
987 |
|
988 |
|
989 |
|
990 |
|
991 |
|
992 |
|
993 |
|
994 |
|
995 |
|
996 |
|
997 |
|
998 |
<div align="justify"> |
999 |
<p style="text-align: justify;"> |
1000 |
|
1001 |
|
1002 |
|
1003 |
</p> |
1004 |
</div> |
1005 |
|
1006 |
|
1007 |
|
1008 |
|
1009 |
|
1010 |
|
1011 |
|
1012 |
|
1013 |
|
1014 |
|
1015 |
|
1016 |
|
1017 |
<div align="justify"> |
1018 |
<p style="text-align: justify;"> |
1019 |
|
1020 |
As with other antimicrobials, avoid direct contact with mucosa and skin. When using wear face/eyes protection, suitable protective clothing and shoes. Do not smoke, eat or drink. After handling thoroughly wash the hands with water and soap. |
1021 |
|
1022 |
</p> |
1023 |
</div> |
1024 |
|
1025 |
|
1026 |
|
1027 |
|
1028 |
|
1029 |
|
1030 |
|
1031 |
|
1032 |
|
1033 |
|
1034 |
|
1035 |
|
1036 |
<div align="justify"> |
1037 |
<p style="text-align: justify;"> |
1038 |
|
1039 |
|
1040 |
|
1041 |
</p> |
1042 |
</div> |
1043 |
|
1044 |
|
1045 |
|
1046 |
|
1047 |
|
1048 |
|
1049 |
|
1050 |
|
1051 |
|
1052 |
|
1053 |
|
1054 |
|
1055 |
<div align="justify"> |
1056 |
<p style="text-align: justify;"> |
1057 |
|
1058 |
In case of contact with eyes, rinse immediately with plenty of water. |
1059 |
|
1060 |
</p> |
1061 |
</div> |
1062 |
|
1063 |
|
1064 |
|
1065 |
|
1066 |
|
1067 |
|
1068 |
|
1069 |
|
1070 |
|
1071 |
|
1072 |
|
1073 |
|
1074 |
<div align="justify"> |
1075 |
<p style="text-align: justify;"> |
1076 |
|
1077 |
|
1078 |
|
1079 |
</p> |
1080 |
</div> |
1081 |
|
1082 |
|
1083 |
|
1084 |
|
1085 |
|
1086 |
|
1087 |
|
1088 |
|
1089 |
|
1090 |
|
1091 |
|
1092 |
|
1093 |
<div align="justify"> |
1094 |
<p style="text-align: justify;"> |
1095 |
|
1096 |
Packaging and leftovers must be disposed of in a safe way. |
1097 |
|
1098 |
</p> |
1099 |
</div> |
1100 |
|
1101 |
|
1102 |
|
1103 |
|
1104 |
|
1105 |
|
1106 |
|
1107 |
|
1108 |
|
1109 |
|
1110 |
|
1111 |
|
1112 |
<div align="justify"> |
1113 |
<p style="text-align: justify;"> |
1114 |
|
1115 |
|
1116 |
|
1117 |
</p> |
1118 |
</div> |
1119 |
|
1120 |
|
1121 |
|
1122 |
|
1123 |
|
1124 |
|
1125 |
|
1126 |
|
1127 |
|
1128 |
|
1129 |
|
1130 |
|
1131 |
<div align="justify"> |
1132 |
<p style="text-align: justify;"> |
1133 |
|
1134 |
Usual pelleting procedure does not diminish potency of the mixed preparation. |
1135 |
|
1136 |
</p> |
1137 |
</div> |
1138 |
|
1139 |
|
1140 |
|
1141 |
|
1142 |
|
1143 |
|
1144 |
|
1145 |
|
1146 |
|
1147 |
|
1148 |
|
1149 |
|
1150 |
<div align="justify"> |
1151 |
<p style="text-align: justify;"> |
1152 |
|
1153 |
|
1154 |
|
1155 |
</p> |
1156 |
</div> |
1157 |
|
1158 |
|
1159 |
|
1160 |
|
1161 |
|
1162 |
|
1163 |
|
1164 |
|
1165 |
|
1166 |
|
1167 |
|
1168 |
|
1169 |
<div align="justify"> |
1170 |
<p style="text-align: justify;"> |
1171 |
|
1172 |
<b><i>Withdrawal</i></b> |
1173 |
|
1174 |
</p> |
1175 |
</div> |
1176 |
|
1177 |
|
1178 |
|
1179 |
|
1180 |
|
1181 |
|
1182 |
|
1183 |
|
1184 |
|
1185 |
|
1186 |
|
1187 |
|
1188 |
<div align="justify"> |
1189 |
<p style="text-align: justify;"> |
1190 |
|
1191 |
Swine - meat 200 ppm with feed 5 days |
1192 |
|
1193 |
</p> |
1194 |
</div> |
1195 |
|
1196 |
|
1197 |
|
1198 |
|
1199 |
|
1200 |
|
1201 |
|
1202 |
|
1203 |
|
1204 |
|
1205 |
|
1206 |
|
1207 |
<div align="justify"> |
1208 |
<p style="text-align: justify;"> |
1209 |
|
1210 |
Swine - meat 25-50 ppm with feed 2 days |
1211 |
|
1212 |
</p> |
1213 |
</div> |
1214 |
|
1215 |
|
1216 |
|
1217 |
|
1218 |
|
1219 |
|
1220 |
|
1221 |
|
1222 |
|
1223 |
|
1224 |
|
1225 |
|
1226 |
<div align="justify"> |
1227 |
<p style="text-align: justify;"> |
1228 |
|
1229 |
Swine - liver 14 days |
1230 |
|
1231 |
</p> |
1232 |
</div> |
1233 |
|
1234 |
|
1235 |
|
1236 |
|
1237 |
|
1238 |
|
1239 |
|
1240 |
|
1241 |
|
1242 |
|
1243 |
|
1244 |
|
1245 |
<div align="justify"> |
1246 |
<p style="text-align: justify;"> |
1247 |
|
1248 |
Broilers - meat and edible tissues 3 days |
1249 |
|
1250 |
</p> |
1251 |
</div> |
1252 |
|
1253 |
|
1254 |
|
1255 |
|
1256 |
|
1257 |
|
1258 |
|
1259 |
|
1260 |
|
1261 |
|
1262 |
|
1263 |
|
1264 |
<div align="justify"> |
1265 |
<p style="text-align: justify;"> |
1266 |
|
1267 |
|
1268 |
|
1269 |
</p> |
1270 |
</div> |
1271 |
|
1272 |
|
1273 |
|
1274 |
|
1275 |
|
1276 |
|
1277 |
|
1278 |
|
1279 |
|
1280 |
|
1281 |
|
1282 |
|
1283 |
<div align="justify"> |
1284 |
<p style="text-align: justify;"> |
1285 |
|
1286 |
<b><i>Storage</i></b> |
1287 |
|
1288 |
</p> |
1289 |
</div> |
1290 |
|
1291 |
|
1292 |
|
1293 |
|
1294 |
|
1295 |
|
1296 |
|
1297 |
|
1298 |
|
1299 |
|
1300 |
|
1301 |
|
1302 |
<div align="justify"> |
1303 |
<p style="text-align: justify;"> |
1304 |
|
1305 |
Store in a dry and ventilated place at 15-25<b><sup>°</sup></b>C. Keep away from children. |
1306 |
|
1307 |
</p> |
1308 |
</div> |
1309 |
|
1310 |
|
1311 |
|
1312 |
|
1313 |
|
1314 |
|
1315 |
|
1316 |
|
1317 |
|
1318 |
|
1319 |
|
1320 |
|
1321 |
<div align="justify"> |
1322 |
<p style="text-align: justify;"> |
1323 |
|
1324 |
|
1325 |
|
1326 |
</p> |
1327 |
</div> |
1328 |
|
1329 |
|
1330 |
|
1331 |
|
1332 |
|
1333 |
|
1334 |
|
1335 |
|
1336 |
|
1337 |
|
1338 |
|
1339 |
|
1340 |
<div align="justify"> |
1341 |
<p style="text-align: justify;"> |
1342 |
|
1343 |
<b><i>Shelf life</i></b> |
1344 |
|
1345 |
</p> |
1346 |
</div> |
1347 |
|
1348 |
|
1349 |
|
1350 |
|
1351 |
|
1352 |
|
1353 |
|
1354 |
|
1355 |
|
1356 |
|
1357 |
|
1358 |
|
1359 |
<div align="justify"> |
1360 |
<p style="text-align: justify;"> |
1361 |
|
1362 |
Denoted on the packaging (2 years in the original pack). |
1363 |
|
1364 |
</p> |
1365 |
</div> |
1366 |
|
1367 |
|
1368 |
|
1369 |
|
1370 |
|
1371 |
|
1372 |
|
1373 |
|
1374 |
|
1375 |
|
1376 |
|
1377 |
|
1378 |
<div align="justify"> |
1379 |
<p style="text-align: justify;"> |
1380 |
|
1381 |
|
1382 |
|
1383 |
</p> |
1384 |
</div> |
1385 |
|
1386 |
|
1387 |
|
1388 |
|
1389 |
|
1390 |
|
1391 |
|
1392 |
|
1393 |
|
1394 |
|
1395 |
|
1396 |
|
1397 |
<div align="justify"> |
1398 |
<p style="text-align: justify;"> |
1399 |
|
1400 |
Tiavet<b><sup>®</sup></b><sup> </sup>2% P mixed with feed or pelleted maintains its potency over 3 months. |
1401 |
|
1402 |
</p> |
1403 |
</div> |
1404 |
|
1405 |
|
1406 |
|
1407 |
|
1408 |
|
1409 |
|
1410 |
|
1411 |
|
1412 |
|
1413 |
|
1414 |
|
1415 |
|
1416 |
<div align="justify"> |
1417 |
<p style="text-align: justify;"> |
1418 |
|
1419 |
<b></b> |
1420 |
|
1421 |
</p> |
1422 |
</div> |
1423 |
|
1424 |
|
1425 |
|
1426 |
|
1427 |
|
1428 |
|
1429 |
|
1430 |
|
1431 |
|
1432 |
|
1433 |
|
1434 |
|
1435 |
<div align="justify"> |
1436 |
<p style="text-align: justify;"> |
1437 |
|
1438 |
<b><i>Legal category</i></b><b></b> |
1439 |
|
1440 |
</p> |
1441 |
</div> |
1442 |
|
1443 |
|
1444 |
|
1445 |
|
1446 |
|
1447 |
|
1448 |
|
1449 |
|
1450 |
|
1451 |
|
1452 |
|
1453 |
|
1454 |
<div align="justify"> |
1455 |
<p style="text-align: justify;"> |
1456 |
|
1457 |
On prescription only or written veterinarian's request to prepare. |
1458 |
|
1459 |
</p> |
1460 |
</div> |
1461 |
|
1462 |
|
1463 |
|
1464 |
|
1465 |
|
1466 |
|
1467 |
|
1468 |
|
1469 |
|
1470 |
|
1471 |
|
1472 |
|
1473 |
<div align="justify"> |
1474 |
<p style="text-align: justify;"> |
1475 |
|
1476 |
<b></b> |
1477 |
|
1478 |
</p> |
1479 |
</div> |
1480 |
|
1481 |
|
1482 |
|
1483 |
|
1484 |
|
1485 |
|
1486 |
|
1487 |
|
1488 |
|
1489 |
|
1490 |
|
1491 |
|
1492 |
<div align="justify"> |
1493 |
<p style="text-align: justify;"> |
1494 |
|
1495 |
<b><i>Supply</i></b> |
1496 |
|
1497 |
</p> |
1498 |
</div> |
1499 |
|
1500 |
|
1501 |
|
1502 |
|
1503 |
|
1504 |
|
1505 |
|
1506 |
|
1507 |
|
1508 |
|
1509 |
|
1510 |
|
1511 |
<div align="justify"> |
1512 |
<p style="text-align: justify;"> |
1513 |
|
1514 |
Bags with 1 kg, boxes with 5 kg and 25 kg. |
1515 |
|
1516 |
</p> |
1517 |
</div> |
1518 |
|
1519 |
|
1520 |
|
1521 |
|
1522 |
|
1523 |
|
1524 |
|
1525 |
|
1526 |
|
1527 |
|
1528 |
|
1529 |
|
1530 |
<div align="justify"> |
1531 |
<p style="text-align: justify;"> |
1532 |
|
1533 |
|
1534 |
|
1535 |
</p> |
1536 |
</div> |
1537 |
|
1538 |
|
1539 |
|
1540 |
|
1541 |
|
1542 |
|
1543 |
|
1544 |
|
1545 |
|
1546 |
|
1547 |
|
1548 |
|
1549 |
<div align="justify"> |
1550 |
<p style="text-align: justify;"> |
1551 |
|
1552 |
<b><i>Manufacturer</i></b><b></b> |
1553 |
|
1554 |
</p> |
1555 |
</div> |
1556 |
|
1557 |
|
1558 |
|
1559 |
|
1560 |
|
1561 |
|
1562 |
|
1563 |
|
1564 |
|
1565 |
|
1566 |
|
1567 |
|
1568 |
<div align="justify"> |
1569 |
<p style="text-align: justify;"> |
1570 |
|
1571 |
VETERINA Animal Health Ltd., Croatia. |
1572 |
|
1573 |
</p> |
1574 |
</div> |
1575 |
|
1576 |
|
1577 |
|
1578 |
|
1579 |
|
1580 |
|
1581 |
|
1582 |
|
1583 |
|
1584 |
|
1585 |
|
1586 |
|
1587 |
<div align="left"> |
1588 |
<p style="text-align: left;"> |
1589 |
|
1590 |
|
1591 |
|
1592 |
</p> |
1593 |
</div> |
1594 |
|
1595 |
|
1596 |
|
1597 |
|
1598 |
|
1599 |
|
1600 |
|
1601 |
|
1602 |
|
1603 |
|
1604 |
|
1605 |
|
1606 |
<div align="left"> |
1607 |
<p style="text-align: left;"> |
1608 |
|
1609 |
|
1610 |
|
1611 |
</p> |
1612 |
</div> |
1613 |
|
1614 |
|
1615 |
|
1616 |
|
1617 |
|
1618 |
|
1619 |
|
1620 |
<!--Section Ends--> |
1621 |
|
1622 |
|
1623 |
|
1624 |
|
1625 |
|
1626 |
|
1627 |
|
1628 |
|