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<!--Section Begins--><br> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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<b>SIMIVET</b><b><sup>®</sup></b><b>15%</b> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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<i>injection suspension</i> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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<b></b> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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<b><i>Composition</i></b><b></b> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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1 mL contains 150 mg of amoxicillin as amoxicillin trihydrate. |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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<b>Action</b> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Amoxicillin is a semi-synthetic penicillin of a broader spectrum in relation to the source benzylpenicillin. As other beta-lactam antibiotics, during bacterial growth it interferes with the synthesis of its cell wall, thus exerting its bactericidal effect. Antimicrobial spectrum of Simivet<b><sup>®</sup></b> covers many gram-positive and gram-negative bacteria: <i>Streptococcus</i> spp., <i>Staphylococcus</i> spp., <i>Erysipelothrix insidiosa</i>, <i>Actinomyces</i> spp., <i>Clostridium</i> spp., <i>Corynebacterium</i> spp., <i>E. coli</i>, <i>Salmonella</i> spp., <i>Actinobacillus</i> spp., <i>Bordetella bronchiseptica</i>, <i>Fusobacterium</i> spp., <i>Haemophilus</i> spp., <i>Moraxella</i> spp., <i>Pasteurella</i> spp., <i>Proteus mirabilis,</i> etc. |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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After i. m. or s. c. administration of Simivet<b><sup>®</sup></b> peak plasma concentrations of amoxicillin are achieved in 2-hours time. Injection suspension is formulated so that a single dose maintains its effective level over 24 hours. Simivet<b><sup>®</sup></b><sup> </sup>is well distributed in majority of tissues, with markedly high levels attained in parenchymal organs, urine and bile. Amoxicillin readily passes through the inflamed respiratory tract membranes to bronchial mucus, thus aiding the treatment of respiratory infections. It is not active upon bacterial beta-lactamase, while bacterial resistance to it is built gradually. Toxicity of amoxicillin is negligible. The doses in excess of the recommended ones are well tolerated. |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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<b><i>Indications</i></b> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Simivet<b><sup>®</sup></b>15% suspension is given to swine, cattle, sheep, dogs and cats for the treatment of general and local, primary and secondary infections due to gram-negative and gram-positive bacteria sensitive to amoxicillin. Major indications are: |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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- general infections, particularly septicemia; |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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- secondary bacterial infections as the outcome of viral diseases; |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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- respiratory infections, e. g. bronchopneumonia in the fattening steers; |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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- gastrointestinal infections; |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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- genitourinary infections including cystitis and metritis; |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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- skin and soft tissue infections: abscess, phlegmon, postoperative infections, omphalitis, panarthritis, paronychia, etc.; |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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- acute mastitis in cows with the change in general condition and concomitant intramammary treatment; |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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- MMA syndrome in sows and erysipelas. |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<b><i>Contraindications</i></b> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Simivet<b><sup>®</sup></b><sup> </sup>injection suspension should not be given by intravenous or intrathecal route. |
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</p> |
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</div> |
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<div align="justify"> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Amoxicillin injection suspension should not be administered to small monogastric herbivore, such as rabbits, guinea-pigs, hamsters, etc. |
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</p> |
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</div> |
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<div align="justify"> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Hypersensitivity to penicillin antibiotics, which is extremely rare. |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Severe renal impairment accompanied by aneuria or oliguria. |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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<b><i>Administration and dosage</i></b> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Simivet<b><sup>®</sup></b>15% is given by i. m. (cattle, swine, sheep, dogs and cats) or s. c. injection (dogs and cats). Shake well before use. |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Average dose for all animals is 1 mL/20 kg of b. w./day (7 mg of amoxicillin/kg of b. w./day). |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Application is repeated every 24 hours. Upon remission of the symptoms the treatment is prolonged over 2 additional days (e. g. 5 days). |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<table width="100.00%" border="1" cols="3" rows="11"> |
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<tr> |
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<td bgcolor="White" width="33.33%" rowspan="1" colspan="1"> |
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<div align="center"> |
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<p style="text-align: center;"> |
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Species and classes |
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</p> |
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</div> |
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</td> |
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<td bgcolor="White" width="33.33%" rowspan="1" colspan="1"> |
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<div align="center"> |
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<p style="text-align: center;"> |
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Body weight (kg) |
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</p> |
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</div> |
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</td> |
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<td bgcolor="White" width="33.33%" rowspan="1" colspan="1"> |
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<div align="center"> |
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<p style="text-align: center;"> |
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Dose of SIMIVET<b><sup>®</sup></b><sup> </sup> 15% |
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</p> |
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</div> |
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</td> |
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</tr> |
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<tr> |
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<td bgcolor="White" width="33.33%" rowspan="1" colspan="1"> |
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<div align="left"> |
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<p style="text-align: left;"> |
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Cattle |
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</p> |
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</div> |
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</td> |
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<td bgcolor="White" width="33.33%" rowspan="1" colspan="1"> |
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<div align="center"> |
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<p style="text-align: center;"> |
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500 |
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</p> |
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</div> |
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</td> |
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<td bgcolor="White" width="33.33%" rowspan="1" colspan="1"> |
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|
853 |
<div align="center"> |
854 |
<p style="text-align: center;"> |
855 |
|
856 |
**50 mL |
857 |
|
858 |
</p> |
859 |
</div> |
860 |
|
861 |
|
862 |
|
863 |
|
864 |
</td> |
865 |
|
866 |
|
867 |
|
868 |
|
869 |
|
870 |
|
871 |
|
872 |
</tr> |
873 |
|
874 |
|
875 |
|
876 |
<tr> |
877 |
<td bgcolor="White" width="33.33%" rowspan="1" colspan="1"> |
878 |
|
879 |
<div align="left"> |
880 |
<p style="text-align: left;"> |
881 |
|
882 |
Calves/steers |
883 |
|
884 |
</p> |
885 |
</div> |
886 |
|
887 |
|
888 |
|
889 |
|
890 |
</td> |
891 |
|
892 |
|
893 |
|
894 |
|
895 |
|
896 |
<td bgcolor="White" width="33.33%" rowspan="1" colspan="1"> |
897 |
|
898 |
<div align="center"> |
899 |
<p style="text-align: center;"> |
900 |
|
901 |
100 |
902 |
|
903 |
</p> |
904 |
</div> |
905 |
|
906 |
|
907 |
|
908 |
|
909 |
</td> |
910 |
|
911 |
|
912 |
|
913 |
|
914 |
|
915 |
<td bgcolor="White" width="33.33%" rowspan="1" colspan="1"> |
916 |
|
917 |
<div align="center"> |
918 |
<p style="text-align: center;"> |
919 |
|
920 |
5mL |
921 |
|
922 |
</p> |
923 |
</div> |
924 |
|
925 |
|
926 |
|
927 |
|
928 |
</td> |
929 |
|
930 |
|
931 |
|
932 |
|
933 |
|
934 |
|
935 |
|
936 |
</tr> |
937 |
|
938 |
|
939 |
|
940 |
<tr> |
941 |
<td bgcolor="White" width="33.33%" rowspan="1" colspan="1"> |
942 |
|
943 |
<div align="left"> |
944 |
<p style="text-align: left;"> |
945 |
|
946 |
Sheep |
947 |
|
948 |
</p> |
949 |
</div> |
950 |
|
951 |
|
952 |
|
953 |
|
954 |
</td> |
955 |
|
956 |
|
957 |
|
958 |
|
959 |
|
960 |
<td bgcolor="White" width="33.33%" rowspan="1" colspan="1"> |
961 |
|
962 |
<div align="center"> |
963 |
<p style="text-align: center;"> |
964 |
|
965 |
50 |
966 |
|
967 |
</p> |
968 |
</div> |
969 |
|
970 |
|
971 |
|
972 |
|
973 |
</td> |
974 |
|
975 |
|
976 |
|
977 |
|
978 |
|
979 |
<td bgcolor="White" width="33.33%" rowspan="1" colspan="1"> |
980 |
|
981 |
<div align="center"> |
982 |
<p style="text-align: center;"> |
983 |
|
984 |
2.5 mL |
985 |
|
986 |
</p> |
987 |
</div> |
988 |
|
989 |
|
990 |
|
991 |
|
992 |
</td> |
993 |
|
994 |
|
995 |
|
996 |
|
997 |
|
998 |
|
999 |
|
1000 |
</tr> |
1001 |
|
1002 |
|
1003 |
|
1004 |
<tr> |
1005 |
<td bgcolor="White" width="33.33%" rowspan="1" colspan="1"> |
1006 |
|
1007 |
<div align="left"> |
1008 |
<p style="text-align: left;"> |
1009 |
|
1010 |
Piglets |
1011 |
|
1012 |
</p> |
1013 |
</div> |
1014 |
|
1015 |
|
1016 |
|
1017 |
|
1018 |
</td> |
1019 |
|
1020 |
|
1021 |
|
1022 |
|
1023 |
|
1024 |
<td bgcolor="White" width="33.33%" rowspan="1" colspan="1"> |
1025 |
|
1026 |
<div align="center"> |
1027 |
<p style="text-align: center;"> |
1028 |
|
1029 |
7-10 |
1030 |
|
1031 |
</p> |
1032 |
</div> |
1033 |
|
1034 |
|
1035 |
|
1036 |
|
1037 |
</td> |
1038 |
|
1039 |
|
1040 |
|
1041 |
|
1042 |
|
1043 |
<td bgcolor="White" width="33.33%" rowspan="1" colspan="1"> |
1044 |
|
1045 |
<div align="center"> |
1046 |
<p style="text-align: center;"> |
1047 |
|
1048 |
0.5 mL |
1049 |
|
1050 |
</p> |
1051 |
</div> |
1052 |
|
1053 |
|
1054 |
|
1055 |
|
1056 |
</td> |
1057 |
|
1058 |
|
1059 |
|
1060 |
|
1061 |
|
1062 |
|
1063 |
|
1064 |
</tr> |
1065 |
|
1066 |
|
1067 |
|
1068 |
<tr> |
1069 |
<td bgcolor="White" width="33.33%" rowspan="1" colspan="1"> |
1070 |
|
1071 |
<div align="left"> |
1072 |
<p style="text-align: left;"> |
1073 |
|
1074 |
Gilts |
1075 |
|
1076 |
</p> |
1077 |
</div> |
1078 |
|
1079 |
|
1080 |
|
1081 |
|
1082 |
</td> |
1083 |
|
1084 |
|
1085 |
|
1086 |
|
1087 |
|
1088 |
<td bgcolor="White" width="33.33%" rowspan="1" colspan="1"> |
1089 |
|
1090 |
<div align="center"> |
1091 |
<p style="text-align: center;"> |
1092 |
|
1093 |
70 |
1094 |
|
1095 |
</p> |
1096 |
</div> |
1097 |
|
1098 |
|
1099 |
|
1100 |
|
1101 |
</td> |
1102 |
|
1103 |
|
1104 |
|
1105 |
|
1106 |
|
1107 |
<td bgcolor="White" width="33.33%" rowspan="1" colspan="1"> |
1108 |
|
1109 |
<div align="center"> |
1110 |
<p style="text-align: center;"> |
1111 |
|
1112 |
3.5 mL |
1113 |
|
1114 |
</p> |
1115 |
</div> |
1116 |
|
1117 |
|
1118 |
|
1119 |
|
1120 |
</td> |
1121 |
|
1122 |
|
1123 |
|
1124 |
|
1125 |
|
1126 |
|
1127 |
|
1128 |
</tr> |
1129 |
|
1130 |
|
1131 |
|
1132 |
<tr> |
1133 |
<td bgcolor="White" width="33.33%" rowspan="1" colspan="1"> |
1134 |
|
1135 |
<div align="left"> |
1136 |
<p style="text-align: left;"> |
1137 |
|
1138 |
Sows |
1139 |
|
1140 |
</p> |
1141 |
</div> |
1142 |
|
1143 |
|
1144 |
|
1145 |
|
1146 |
</td> |
1147 |
|
1148 |
|
1149 |
|
1150 |
|
1151 |
|
1152 |
<td bgcolor="White" width="33.33%" rowspan="1" colspan="1"> |
1153 |
|
1154 |
<div align="center"> |
1155 |
<p style="text-align: center;"> |
1156 |
|
1157 |
150 |
1158 |
|
1159 |
</p> |
1160 |
</div> |
1161 |
|
1162 |
|
1163 |
|
1164 |
|
1165 |
</td> |
1166 |
|
1167 |
|
1168 |
|
1169 |
|
1170 |
|
1171 |
<td bgcolor="White" width="33.33%" rowspan="1" colspan="1"> |
1172 |
|
1173 |
<div align="center"> |
1174 |
<p style="text-align: center;"> |
1175 |
|
1176 |
7.5 mL |
1177 |
|
1178 |
</p> |
1179 |
</div> |
1180 |
|
1181 |
|
1182 |
|
1183 |
|
1184 |
</td> |
1185 |
|
1186 |
|
1187 |
|
1188 |
|
1189 |
|
1190 |
|
1191 |
|
1192 |
</tr> |
1193 |
|
1194 |
|
1195 |
|
1196 |
<tr> |
1197 |
<td bgcolor="White" width="33.33%" rowspan="1" colspan="1"> |
1198 |
|
1199 |
<div align="left"> |
1200 |
<p style="text-align: left;"> |
1201 |
|
1202 |
Small dogs |
1203 |
|
1204 |
</p> |
1205 |
</div> |
1206 |
|
1207 |
|
1208 |
|
1209 |
|
1210 |
</td> |
1211 |
|
1212 |
|
1213 |
|
1214 |
|
1215 |
|
1216 |
<td bgcolor="White" width="33.33%" rowspan="1" colspan="1"> |
1217 |
|
1218 |
<div align="center"> |
1219 |
<p style="text-align: center;"> |
1220 |
|
1221 |
10 |
1222 |
|
1223 |
</p> |
1224 |
</div> |
1225 |
|
1226 |
|
1227 |
|
1228 |
|
1229 |
</td> |
1230 |
|
1231 |
|
1232 |
|
1233 |
|
1234 |
|
1235 |
<td bgcolor="White" width="33.33%" rowspan="1" colspan="1"> |
1236 |
|
1237 |
<div align="center"> |
1238 |
<p style="text-align: center;"> |
1239 |
|
1240 |
0.5 mL |
1241 |
|
1242 |
</p> |
1243 |
</div> |
1244 |
|
1245 |
|
1246 |
|
1247 |
|
1248 |
</td> |
1249 |
|
1250 |
|
1251 |
|
1252 |
|
1253 |
|
1254 |
|
1255 |
|
1256 |
</tr> |
1257 |
|
1258 |
|
1259 |
|
1260 |
<tr> |
1261 |
<td bgcolor="White" width="33.33%" rowspan="1" colspan="1"> |
1262 |
|
1263 |
<div align="left"> |
1264 |
<p style="text-align: left;"> |
1265 |
|
1266 |
Medium dogs |
1267 |
|
1268 |
</p> |
1269 |
</div> |
1270 |
|
1271 |
|
1272 |
|
1273 |
|
1274 |
</td> |
1275 |
|
1276 |
|
1277 |
|
1278 |
|
1279 |
|
1280 |
<td bgcolor="White" width="33.33%" rowspan="1" colspan="1"> |
1281 |
|
1282 |
<div align="center"> |
1283 |
<p style="text-align: center;"> |
1284 |
|
1285 |
20 |
1286 |
|
1287 |
</p> |
1288 |
</div> |
1289 |
|
1290 |
|
1291 |
|
1292 |
|
1293 |
</td> |
1294 |
|
1295 |
|
1296 |
|
1297 |
|
1298 |
|
1299 |
<td bgcolor="White" width="33.33%" rowspan="1" colspan="1"> |
1300 |
|
1301 |
<div align="center"> |
1302 |
<p style="text-align: center;"> |
1303 |
|
1304 |
1.0 mL |
1305 |
|
1306 |
</p> |
1307 |
</div> |
1308 |
|
1309 |
|
1310 |
|
1311 |
|
1312 |
</td> |
1313 |
|
1314 |
|
1315 |
|
1316 |
|
1317 |
|
1318 |
|
1319 |
|
1320 |
</tr> |
1321 |
|
1322 |
|
1323 |
|
1324 |
<tr> |
1325 |
<td bgcolor="White" width="33.33%" rowspan="1" colspan="1"> |
1326 |
|
1327 |
<div align="left"> |
1328 |
<p style="text-align: left;"> |
1329 |
|
1330 |
Large dogs |
1331 |
|
1332 |
</p> |
1333 |
</div> |
1334 |
|
1335 |
|
1336 |
|
1337 |
|
1338 |
</td> |
1339 |
|
1340 |
|
1341 |
|
1342 |
|
1343 |
|
1344 |
<td bgcolor="White" width="33.33%" rowspan="1" colspan="1"> |
1345 |
|
1346 |
<div align="center"> |
1347 |
<p style="text-align: center;"> |
1348 |
|
1349 |
35 |
1350 |
|
1351 |
</p> |
1352 |
</div> |
1353 |
|
1354 |
|
1355 |
|
1356 |
|
1357 |
</td> |
1358 |
|
1359 |
|
1360 |
|
1361 |
|
1362 |
|
1363 |
<td bgcolor="White" width="33.33%" rowspan="1" colspan="1"> |
1364 |
|
1365 |
<div align="center"> |
1366 |
<p style="text-align: center;"> |
1367 |
|
1368 |
2.5 mL |
1369 |
|
1370 |
</p> |
1371 |
</div> |
1372 |
|
1373 |
|
1374 |
|
1375 |
|
1376 |
</td> |
1377 |
|
1378 |
|
1379 |
|
1380 |
|
1381 |
|
1382 |
|
1383 |
|
1384 |
</tr> |
1385 |
|
1386 |
|
1387 |
|
1388 |
<tr> |
1389 |
<td bgcolor="White" width="33.33%" rowspan="1" colspan="1"> |
1390 |
|
1391 |
<div align="left"> |
1392 |
<p style="text-align: left;"> |
1393 |
|
1394 |
Cats |
1395 |
|
1396 |
</p> |
1397 |
</div> |
1398 |
|
1399 |
|
1400 |
|
1401 |
|
1402 |
</td> |
1403 |
|
1404 |
|
1405 |
|
1406 |
|
1407 |
|
1408 |
<td bgcolor="White" width="33.33%" rowspan="1" colspan="1"> |
1409 |
|
1410 |
<div align="center"> |
1411 |
<p style="text-align: center;"> |
1412 |
|
1413 |
5 |
1414 |
|
1415 |
</p> |
1416 |
</div> |
1417 |
|
1418 |
|
1419 |
|
1420 |
|
1421 |
</td> |
1422 |
|
1423 |
|
1424 |
|
1425 |
|
1426 |
|
1427 |
<td bgcolor="White" width="33.33%" rowspan="1" colspan="1"> |
1428 |
|
1429 |
<div align="center"> |
1430 |
<p style="text-align: center;"> |
1431 |
|
1432 |
0.25 mL |
1433 |
|
1434 |
</p> |
1435 |
</div> |
1436 |
|
1437 |
|
1438 |
|
1439 |
|
1440 |
</td> |
1441 |
|
1442 |
|
1443 |
|
1444 |
|
1445 |
|
1446 |
|
1447 |
|
1448 |
</tr> |
1449 |
|
1450 |
</table> |
1451 |
|
1452 |
|
1453 |
|
1454 |
|
1455 |
<div align="justify"> |
1456 |
<p style="text-align: justify;"> |
1457 |
|
1458 |
|
1459 |
|
1460 |
</p> |
1461 |
</div> |
1462 |
|
1463 |
|
1464 |
|
1465 |
|
1466 |
|
1467 |
|
1468 |
|
1469 |
|
1470 |
|
1471 |
|
1472 |
|
1473 |
|
1474 |
<div align="justify"> |
1475 |
<p style="text-align: justify;"> |
1476 |
|
1477 |
** Doses above 20 mL should be injected at two sites. |
1478 |
|
1479 |
</p> |
1480 |
</div> |
1481 |
|
1482 |
|
1483 |
|
1484 |
|
1485 |
|
1486 |
|
1487 |
|
1488 |
|
1489 |
|
1490 |
|
1491 |
|
1492 |
|
1493 |
<div align="justify"> |
1494 |
<p style="text-align: justify;"> |
1495 |
|
1496 |
|
1497 |
|
1498 |
</p> |
1499 |
</div> |
1500 |
|
1501 |
|
1502 |
|
1503 |
|
1504 |
|
1505 |
|
1506 |
|
1507 |
|
1508 |
|
1509 |
|
1510 |
|
1511 |
|
1512 |
<div align="justify"> |
1513 |
<p style="text-align: justify;"> |
1514 |
|
1515 |
After administering to cats and dogs gently massage the site of application. |
1516 |
|
1517 |
</p> |
1518 |
</div> |
1519 |
|
1520 |
|
1521 |
|
1522 |
|
1523 |
|
1524 |
|
1525 |
|
1526 |
|
1527 |
|
1528 |
|
1529 |
|
1530 |
|
1531 |
<div align="justify"> |
1532 |
<p style="text-align: justify;"> |
1533 |
|
1534 |
|
1535 |
|
1536 |
</p> |
1537 |
</div> |
1538 |
|
1539 |
|
1540 |
|
1541 |
|
1542 |
|
1543 |
|
1544 |
|
1545 |
|
1546 |
|
1547 |
|
1548 |
|
1549 |
|
1550 |
<div align="justify"> |
1551 |
<p style="text-align: justify;"> |
1552 |
|
1553 |
Higher doses efficiently manage gram-negative infections, bacterial inflammations of respiratory tract and diseases in young animals. |
1554 |
|
1555 |
</p> |
1556 |
</div> |
1557 |
|
1558 |
|
1559 |
|
1560 |
|
1561 |
|
1562 |
|
1563 |
|
1564 |
|
1565 |
|
1566 |
|
1567 |
|
1568 |
|
1569 |
<div align="justify"> |
1570 |
<p style="text-align: justify;"> |
1571 |
|
1572 |
|
1573 |
|
1574 |
</p> |
1575 |
</div> |
1576 |
|
1577 |
|
1578 |
|
1579 |
|
1580 |
|
1581 |
|
1582 |
|
1583 |
|
1584 |
|
1585 |
|
1586 |
|
1587 |
|
1588 |
<div align="justify"> |
1589 |
<p style="text-align: justify;"> |
1590 |
|
1591 |
<b><i>Side effects</i></b> |
1592 |
|
1593 |
</p> |
1594 |
</div> |
1595 |
|
1596 |
|
1597 |
|
1598 |
|
1599 |
|
1600 |
|
1601 |
|
1602 |
|
1603 |
|
1604 |
|
1605 |
|
1606 |
|
1607 |
<div align="justify"> |
1608 |
<p style="text-align: justify;"> |
1609 |
|
1610 |
Transient swelling may develop at the site of injection, which disappears a few days from administration. |
1611 |
|
1612 |
</p> |
1613 |
</div> |
1614 |
|
1615 |
|
1616 |
|
1617 |
|
1618 |
|
1619 |
|
1620 |
|
1621 |
|
1622 |
|
1623 |
|
1624 |
|
1625 |
|
1626 |
<div align="justify"> |
1627 |
<p style="text-align: justify;"> |
1628 |
|
1629 |
|
1630 |
|
1631 |
</p> |
1632 |
</div> |
1633 |
|
1634 |
|
1635 |
|
1636 |
|
1637 |
|
1638 |
|
1639 |
|
1640 |
|
1641 |
|
1642 |
|
1643 |
|
1644 |
|
1645 |
<div align="justify"> |
1646 |
<p style="text-align: justify;"> |
1647 |
|
1648 |
<b><i>Warnings, precautions and interactions</i></b> |
1649 |
|
1650 |
</p> |
1651 |
</div> |
1652 |
|
1653 |
|
1654 |
|
1655 |
|
1656 |
|
1657 |
|
1658 |
|
1659 |
|
1660 |
|
1661 |
|
1662 |
|
1663 |
|
1664 |
<div align="justify"> |
1665 |
<p style="text-align: justify;"> |
1666 |
|
1667 |
Like other penicillin antibiotics, Simivet<b><sup>®</sup></b> suspension is unstable in water. Use dry and sterile needles and syringes for withdrawal of the vaccine from the bottle and for its administration. |
1668 |
|
1669 |
</p> |
1670 |
</div> |
1671 |
|
1672 |
|
1673 |
|
1674 |
|
1675 |
|
1676 |
|
1677 |
|
1678 |
|
1679 |
|
1680 |
|
1681 |
|
1682 |
|
1683 |
<div align="justify"> |
1684 |
<p style="text-align: justify;"> |
1685 |
|
1686 |
|
1687 |
|
1688 |
</p> |
1689 |
</div> |
1690 |
|
1691 |
|
1692 |
|
1693 |
|
1694 |
|
1695 |
|
1696 |
|
1697 |
|
1698 |
|
1699 |
|
1700 |
|
1701 |
|
1702 |
<div align="justify"> |
1703 |
<p style="text-align: justify;"> |
1704 |
|
1705 |
Antimicrobial action of amoxicillin is reduced by concomitant administration of tetracyclines, macrolides and chloramphenicol. |
1706 |
|
1707 |
</p> |
1708 |
</div> |
1709 |
|
1710 |
|
1711 |
|
1712 |
|
1713 |
|
1714 |
|
1715 |
|
1716 |
|
1717 |
|
1718 |
|
1719 |
|
1720 |
|
1721 |
<div align="justify"> |
1722 |
<p style="text-align: justify;"> |
1723 |
|
1724 |
|
1725 |
|
1726 |
</p> |
1727 |
</div> |
1728 |
|
1729 |
|
1730 |
|
1731 |
|
1732 |
|
1733 |
|
1734 |
|
1735 |
|
1736 |
|
1737 |
|
1738 |
|
1739 |
|
1740 |
<div align="justify"> |
1741 |
<p style="text-align: justify;"> |
1742 |
|
1743 |
If after three days of treatment there is no apparent improvement, the preparation may be continued only if laboratory tests show sensitivity of the causative organism to amoxicillin. |
1744 |
|
1745 |
</p> |
1746 |
</div> |
1747 |
|
1748 |
|
1749 |
|
1750 |
|
1751 |
|
1752 |
|
1753 |
|
1754 |
|
1755 |
|
1756 |
|
1757 |
|
1758 |
|
1759 |
<div align="justify"> |
1760 |
<p style="text-align: justify;"> |
1761 |
|
1762 |
|
1763 |
|
1764 |
</p> |
1765 |
</div> |
1766 |
|
1767 |
|
1768 |
|
1769 |
|
1770 |
|
1771 |
|
1772 |
|
1773 |
|
1774 |
|
1775 |
|
1776 |
|
1777 |
|
1778 |
<div align="justify"> |
1779 |
<p style="text-align: justify;"> |
1780 |
|
1781 |
<b><i>Withdrawal</i></b> |
1782 |
|
1783 |
</p> |
1784 |
</div> |
1785 |
|
1786 |
|
1787 |
|
1788 |
|
1789 |
|
1790 |
|
1791 |
|
1792 |
|
1793 |
|
1794 |
|
1795 |
|
1796 |
|
1797 |
<div align="justify"> |
1798 |
<p style="text-align: justify;"> |
1799 |
|
1800 |
Meat and other edible tissues 14 days. |
1801 |
|
1802 |
</p> |
1803 |
</div> |
1804 |
|
1805 |
|
1806 |
|
1807 |
|
1808 |
|
1809 |
|
1810 |
|
1811 |
|
1812 |
|
1813 |
|
1814 |
|
1815 |
|
1816 |
<div align="justify"> |
1817 |
<p style="text-align: justify;"> |
1818 |
|
1819 |
Cow milk 24 hours. |
1820 |
|
1821 |
</p> |
1822 |
</div> |
1823 |
|
1824 |
|
1825 |
|
1826 |
|
1827 |
|
1828 |
|
1829 |
|
1830 |
|
1831 |
|
1832 |
|
1833 |
|
1834 |
|
1835 |
<div align="justify"> |
1836 |
<p style="text-align: justify;"> |
1837 |
|
1838 |
|
1839 |
|
1840 |
</p> |
1841 |
</div> |
1842 |
|
1843 |
|
1844 |
|
1845 |
|
1846 |
|
1847 |
|
1848 |
|
1849 |
|
1850 |
|
1851 |
|
1852 |
|
1853 |
|
1854 |
<div align="justify"> |
1855 |
<p style="text-align: justify;"> |
1856 |
|
1857 |
<b><i>Storage</i></b> |
1858 |
|
1859 |
</p> |
1860 |
</div> |
1861 |
|
1862 |
|
1863 |
|
1864 |
|
1865 |
|
1866 |
|
1867 |
|
1868 |
|
1869 |
|
1870 |
|
1871 |
|
1872 |
|
1873 |
<div align="justify"> |
1874 |
<p style="text-align: justify;"> |
1875 |
|
1876 |
Store in a dark and cool place (8-15°C). Keep away from children. Avoid freezing. |
1877 |
|
1878 |
</p> |
1879 |
</div> |
1880 |
|
1881 |
|
1882 |
|
1883 |
|
1884 |
|
1885 |
|
1886 |
|
1887 |
|
1888 |
|
1889 |
|
1890 |
|
1891 |
|
1892 |
<div align="justify"> |
1893 |
<p style="text-align: justify;"> |
1894 |
|
1895 |
|
1896 |
|
1897 |
</p> |
1898 |
</div> |
1899 |
|
1900 |
|
1901 |
|
1902 |
|
1903 |
|
1904 |
|
1905 |
|
1906 |
|
1907 |
|
1908 |
|
1909 |
|
1910 |
|
1911 |
<div align="justify"> |
1912 |
<p style="text-align: justify;"> |
1913 |
|
1914 |
<b><i>Shelf life</i></b> |
1915 |
|
1916 |
</p> |
1917 |
</div> |
1918 |
|
1919 |
|
1920 |
|
1921 |
|
1922 |
|
1923 |
|
1924 |
|
1925 |
|
1926 |
|
1927 |
|
1928 |
|
1929 |
|
1930 |
<div align="justify"> |
1931 |
<p style="text-align: justify;"> |
1932 |
|
1933 |
Denoted on the packaging (3 years in the original pack).<b><i></i></b> |
1934 |
|
1935 |
</p> |
1936 |
</div> |
1937 |
|
1938 |
|
1939 |
|
1940 |
|
1941 |
|
1942 |
|
1943 |
|
1944 |
|
1945 |
|
1946 |
|
1947 |
|
1948 |
|
1949 |
<div align="justify"> |
1950 |
<p style="text-align: justify;"> |
1951 |
|
1952 |
|
1953 |
|
1954 |
</p> |
1955 |
</div> |
1956 |
|
1957 |
|
1958 |
|
1959 |
|
1960 |
|
1961 |
|
1962 |
|
1963 |
|
1964 |
|
1965 |
|
1966 |
|
1967 |
|
1968 |
<div align="justify"> |
1969 |
<p style="text-align: justify;"> |
1970 |
|
1971 |
Legal category |
1972 |
|
1973 |
</p> |
1974 |
</div> |
1975 |
|
1976 |
|
1977 |
|
1978 |
|
1979 |
|
1980 |
|
1981 |
|
1982 |
|
1983 |
|
1984 |
|
1985 |
|
1986 |
|
1987 |
<div align="justify"> |
1988 |
<p style="text-align: justify;"> |
1989 |
|
1990 |
On prescription only. |
1991 |
|
1992 |
</p> |
1993 |
</div> |
1994 |
|
1995 |
|
1996 |
|
1997 |
|
1998 |
|
1999 |
|
2000 |
|
2001 |
|
2002 |
|
2003 |
|
2004 |
|
2005 |
|
2006 |
<div align="justify"> |
2007 |
<p style="text-align: justify;"> |
2008 |
|
2009 |
|
2010 |
|
2011 |
</p> |
2012 |
</div> |
2013 |
|
2014 |
|
2015 |
|
2016 |
|
2017 |
|
2018 |
|
2019 |
|
2020 |
|
2021 |
|
2022 |
|
2023 |
|
2024 |
|
2025 |
<div align="justify"> |
2026 |
<p style="text-align: justify;"> |
2027 |
|
2028 |
<b><i>Supply</i></b> |
2029 |
|
2030 |
</p> |
2031 |
</div> |
2032 |
|
2033 |
|
2034 |
|
2035 |
|
2036 |
|
2037 |
|
2038 |
|
2039 |
|
2040 |
|
2041 |
|
2042 |
|
2043 |
|
2044 |
<div align="justify"> |
2045 |
<p style="text-align: justify;"> |
2046 |
|
2047 |
Pierced bottle of 100 mL |
2048 |
|
2049 |
</p> |
2050 |
</div> |
2051 |
|
2052 |
|
2053 |
|
2054 |
|
2055 |
|
2056 |
|
2057 |
|
2058 |
|
2059 |
|
2060 |
|
2061 |
|
2062 |
|
2063 |
<div align="justify"> |
2064 |
<p style="text-align: justify;"> |
2065 |
|
2066 |
Box with 6x100 mL. |
2067 |
|
2068 |
</p> |
2069 |
</div> |
2070 |
|
2071 |
|
2072 |
|
2073 |
|
2074 |
|
2075 |
|
2076 |
|
2077 |
|
2078 |
|
2079 |
|
2080 |
|
2081 |
|
2082 |
<div align="justify"> |
2083 |
<p style="text-align: justify;"> |
2084 |
|
2085 |
|
2086 |
|
2087 |
</p> |
2088 |
</div> |
2089 |
|
2090 |
|
2091 |
|
2092 |
|
2093 |
|
2094 |
|
2095 |
|
2096 |
|
2097 |
|
2098 |
|
2099 |
|
2100 |
|
2101 |
<div align="justify"> |
2102 |
<p style="text-align: justify;"> |
2103 |
|
2104 |
<b><i>Manufacturer</i></b> |
2105 |
|
2106 |
</p> |
2107 |
</div> |
2108 |
|
2109 |
|
2110 |
|
2111 |
|
2112 |
|
2113 |
|
2114 |
|
2115 |
|
2116 |
|
2117 |
|
2118 |
|
2119 |
|
2120 |
<div align="justify"> |
2121 |
<p style="text-align: justify;"> |
2122 |
|
2123 |
VETERINA Animal Health Ltd., Croatia |
2124 |
|
2125 |
</p> |
2126 |
</div> |
2127 |
|
2128 |
|
2129 |
|
2130 |
|
2131 |
|
2132 |
|
2133 |
|
2134 |
|
2135 |
|
2136 |
|
2137 |
|
2138 |
|
2139 |
<div align="justify"> |
2140 |
<p style="text-align: justify;"> |
2141 |
|
2142 |
<b></b> |
2143 |
|
2144 |
</p> |
2145 |
</div> |
2146 |
|
2147 |
|
2148 |
|
2149 |
|
2150 |
|
2151 |
|
2152 |
|
2153 |
|
2154 |
|
2155 |
|
2156 |
|
2157 |
|
2158 |
<div align="justify"> |
2159 |
<p style="text-align: justify;"> |
2160 |
|
2161 |
|
2162 |
|
2163 |
</p> |
2164 |
</div> |
2165 |
|
2166 |
|
2167 |
|
2168 |
|
2169 |
|
2170 |
|
2171 |
|
2172 |
|
2173 |
|
2174 |
|
2175 |
|
2176 |
|
2177 |
<div align="left"> |
2178 |
<p style="text-align: left;"> |
2179 |
|
2180 |
|
2181 |
|
2182 |
</p> |
2183 |
</div> |
2184 |
|
2185 |
|
2186 |
|
2187 |
|
2188 |
|
2189 |
|
2190 |
|
2191 |
<!--Section Ends--> |
2192 |
|
2193 |
|
2194 |
|
2195 |
|
2196 |
|
2197 |
|
2198 |
|
2199 |
|