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<!--Section Begins--><br> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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<b></b> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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NUTRICIN SULFA<b><sup>®</sup></b><b> 140</b> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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<i>medicated additive</i> |
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</p> |
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</div> |
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<div align="justify"> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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<b><i>Composition</i></b><b></b> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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1 kg contains: |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Oxytetracycline hydrochloride 60 g |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Neomycin sulfate 30 g |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Sulfadimidine 25 g |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Sulfaguanidine 25 g |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Citric acid 100 g |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Vegetable carrier and adjuvants up to 1000 g |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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<b><i>Action</i></b><b></b> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Nutricin Sulfa<b><sup>®</sup></b>140<b> </b>is a combination of active ingredients, which complement one another in their spectrum of activity and increase sensitivity of the bacteria frequently causing health problems, particularly in young animals. |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Oxytetracycline and neomycin act bacteriostatically by inhibiting bacterial protein synthesis. The combination of these two antibiotics ensures systemic and local effect, which is due to rapid and good resorption of oxytetracycline and poor resorption of neomycin. Their antimicrobial spectrum covers many gram-positive and gram-negative organisms: <i>E. coli, Salmonella</i> spp., <i>Bordetella</i> spp., <i>Proteus</i> spp., <i>Pseudomonas</i> spp., <i>Streptococcus</i> spp., <i>Staphylococcus</i> spp., spirochetes, rickettsiae and actinomycetes. |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Sulfonamides have more potent bacteriostatic effect on gram-positive bacteria by inhibiting the synthesis of folic acid, and thus metabolism of nucleic acids, which is important for cell reproduction. Unlike sulfadimidine, sulfaguanidine has limited intestinal resorption and thus effect limited to gastrointestinal tract. |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Citric acid adds to the effect of antimicrobials by reducing gastric and intestinal pH and inhibiting the growth of coli bacteria and total anaerobes. It improves disintegration of the rations, which contributes to more rapid recovery and increases performance of the animals. |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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<b><i>Indications</i></b> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Metaphylaxis and treatment of primary and secondary bacterial infections, particularly of gastrointestinal tact in piglets, swine, suckling calves and poultry. |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Alleviation of stress effect caused by weaning, change of feed, housing and keeping conditions, vaccination, castration, transportation, etc. |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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<b><i>Contraindications</i></b> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Severe renal and hepatic impairment. |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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583 |
<b><i>Administration and dosage</i></b><b></b> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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<i>Piglets:</i> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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The drug is given homogeneously mixed with feed in the concentration of 0.5% (e. g. 100 kg of feed is mixed with 0.5 kg of Nutricin Sulfa<b><sup>®</sup></b> 140 powder) given over 5 consecutive days or longer, if necessary. In case of atrophic rhinitis administration may be prolonged up to 6 weeks post weaning. |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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<i>Calves:</i> |
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</p> |
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</div> |
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664 |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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Daily dose for the calves with undeveloped rumen is 20 g (ca 3 levelled tablespoonfuls) per 50 kg of b. w. Administration is per os, re-suspended in some liquid (water, milk, milk supplement, tea or whey) or, relevant to the age, mixed with some concentrate (top dressing). The drug is given over 5 consecutive days, always freshly prepared. |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
696 |
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</p> |
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</div> |
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<div align="justify"> |
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<p style="text-align: justify;"> |
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<i>Chicks:</i> |
717 |
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</p> |
719 |
</div> |
720 |
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721 |
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722 |
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723 |
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724 |
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|
731 |
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<div align="justify"> |
733 |
<p style="text-align: justify;"> |
734 |
|
735 |
To prevent early mortality the drug is mixed with feed in the concentration of 0.15% and is given over the first 14 days of life. Chronic respiratory disease (CRD) is prevented by administering the drug with flour feed in 0.25% concentration given during first 5 days of life. In the increased risk, metaphylaxis should be repeated in week 4 of life with the same dose and over 5 consecutive days. Gastrointestinal infections (bacterial and non-specific enteritis) and infectious sinovitis are managed with 0.35% concentration given over 5-7 days. When gastrointestinal diseases are the complication of CRD, Nutricin Sulfa<b><sup>®</sup></b> 140<b> </b>is added to feed in 0.4-0.5% concentration and administered over 5-7 consecutive days or longer, if necessary. |
736 |
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</p> |
738 |
</div> |
739 |
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740 |
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741 |
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742 |
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743 |
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744 |
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746 |
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747 |
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748 |
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749 |
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750 |
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<div align="justify"> |
752 |
<p style="text-align: justify;"> |
753 |
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754 |
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755 |
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</p> |
757 |
</div> |
758 |
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759 |
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764 |
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766 |
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768 |
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769 |
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770 |
<div align="justify"> |
771 |
<p style="text-align: justify;"> |
772 |
|
773 |
<i>Poultry:</i> |
774 |
|
775 |
</p> |
776 |
</div> |
777 |
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778 |
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779 |
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780 |
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781 |
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782 |
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783 |
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784 |
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785 |
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786 |
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787 |
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788 |
|
789 |
<div align="justify"> |
790 |
<p style="text-align: justify;"> |
791 |
|
792 |
Early mortality, bacterial and non-specific enteritis and stress are controlled and managed with Nutricin Sulfa<b><sup>®</sup></b> 140<b> </b>mixed with feed in 0.15% concentration and administered over first 4 weeks of life. Bacterial and non-specific enteritis (blue comb), hexamitiasis and infectious sinusitis and sinovitis are treated with 0.35% concentration given over 5-7 days. Inflammation of air sac, early mortality and untoward effects of the infection upon gain and feed conversion are managed with 0.35% concentration. |
793 |
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794 |
</p> |
795 |
</div> |
796 |
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797 |
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798 |
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799 |
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800 |
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801 |
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802 |
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803 |
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804 |
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805 |
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806 |
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807 |
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808 |
<div align="justify"> |
809 |
<p style="text-align: justify;"> |
810 |
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811 |
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812 |
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813 |
</p> |
814 |
</div> |
815 |
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816 |
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817 |
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818 |
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819 |
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820 |
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821 |
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822 |
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823 |
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824 |
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825 |
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826 |
|
827 |
<div align="justify"> |
828 |
<p style="text-align: justify;"> |
829 |
|
830 |
<b><i>Warnings and precautions</i></b><b></b> |
831 |
|
832 |
</p> |
833 |
</div> |
834 |
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835 |
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836 |
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837 |
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838 |
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839 |
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840 |
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841 |
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842 |
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843 |
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844 |
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845 |
|
846 |
<div align="justify"> |
847 |
<p style="text-align: justify;"> |
848 |
|
849 |
Sick animals taking scarce feed should be treated parenterally. |
850 |
|
851 |
</p> |
852 |
</div> |
853 |
|
854 |
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855 |
|
856 |
|
857 |
|
858 |
|
859 |
|
860 |
|
861 |
|
862 |
|
863 |
|
864 |
|
865 |
<div align="justify"> |
866 |
<p style="text-align: justify;"> |
867 |
|
868 |
|
869 |
|
870 |
</p> |
871 |
</div> |
872 |
|
873 |
|
874 |
|
875 |
|
876 |
|
877 |
|
878 |
|
879 |
|
880 |
|
881 |
|
882 |
|
883 |
|
884 |
<div align="justify"> |
885 |
<p style="text-align: justify;"> |
886 |
|
887 |
Administration to the commercial laying hens is inadvisable. |
888 |
|
889 |
</p> |
890 |
</div> |
891 |
|
892 |
|
893 |
|
894 |
|
895 |
|
896 |
|
897 |
|
898 |
|
899 |
|
900 |
|
901 |
|
902 |
|
903 |
<div align="justify"> |
904 |
<p style="text-align: justify;"> |
905 |
|
906 |
|
907 |
|
908 |
</p> |
909 |
</div> |
910 |
|
911 |
|
912 |
|
913 |
|
914 |
|
915 |
|
916 |
|
917 |
|
918 |
|
919 |
|
920 |
|
921 |
|
922 |
<div align="justify"> |
923 |
<p style="text-align: justify;"> |
924 |
|
925 |
Usual pelleting process does not diminish potency of the mixed preparation. |
926 |
|
927 |
</p> |
928 |
</div> |
929 |
|
930 |
|
931 |
|
932 |
|
933 |
|
934 |
|
935 |
|
936 |
|
937 |
|
938 |
|
939 |
|
940 |
|
941 |
<div align="justify"> |
942 |
<p style="text-align: justify;"> |
943 |
|
944 |
<b></b> |
945 |
|
946 |
</p> |
947 |
</div> |
948 |
|
949 |
|
950 |
|
951 |
|
952 |
|
953 |
|
954 |
|
955 |
|
956 |
|
957 |
|
958 |
|
959 |
|
960 |
<div align="justify"> |
961 |
<p style="text-align: justify;"> |
962 |
|
963 |
<b><i>Side effects</i></b> |
964 |
|
965 |
</p> |
966 |
</div> |
967 |
|
968 |
|
969 |
|
970 |
|
971 |
|
972 |
|
973 |
|
974 |
|
975 |
|
976 |
|
977 |
|
978 |
|
979 |
<div align="justify"> |
980 |
<p style="text-align: justify;"> |
981 |
|
982 |
Unknown. |
983 |
|
984 |
</p> |
985 |
</div> |
986 |
|
987 |
|
988 |
|
989 |
|
990 |
|
991 |
|
992 |
|
993 |
|
994 |
|
995 |
|
996 |
|
997 |
|
998 |
<div align="justify"> |
999 |
<p style="text-align: justify;"> |
1000 |
|
1001 |
|
1002 |
|
1003 |
</p> |
1004 |
</div> |
1005 |
|
1006 |
|
1007 |
|
1008 |
|
1009 |
|
1010 |
|
1011 |
|
1012 |
|
1013 |
|
1014 |
|
1015 |
|
1016 |
|
1017 |
<div align="justify"> |
1018 |
<p style="text-align: justify;"> |
1019 |
|
1020 |
<b>Withdrawal</b> |
1021 |
|
1022 |
</p> |
1023 |
</div> |
1024 |
|
1025 |
|
1026 |
|
1027 |
|
1028 |
|
1029 |
|
1030 |
|
1031 |
|
1032 |
|
1033 |
|
1034 |
|
1035 |
|
1036 |
<div align="justify"> |
1037 |
<p style="text-align: justify;"> |
1038 |
|
1039 |
Meat |
1040 |
|
1041 |
</p> |
1042 |
</div> |
1043 |
|
1044 |
|
1045 |
|
1046 |
|
1047 |
|
1048 |
|
1049 |
|
1050 |
|
1051 |
|
1052 |
|
1053 |
|
1054 |
|
1055 |
<div align="justify"> |
1056 |
<p style="text-align: justify;"> |
1057 |
|
1058 |
- calves, swine 10 days |
1059 |
|
1060 |
</p> |
1061 |
</div> |
1062 |
|
1063 |
|
1064 |
|
1065 |
|
1066 |
|
1067 |
|
1068 |
|
1069 |
|
1070 |
|
1071 |
|
1072 |
|
1073 |
|
1074 |
<div align="justify"> |
1075 |
<p style="text-align: justify;"> |
1076 |
|
1077 |
- broilers and poultry 7 days |
1078 |
|
1079 |
</p> |
1080 |
</div> |
1081 |
|
1082 |
|
1083 |
|
1084 |
|
1085 |
|
1086 |
|
1087 |
|
1088 |
|
1089 |
|
1090 |
|
1091 |
|
1092 |
|
1093 |
<div align="justify"> |
1094 |
<p style="text-align: justify;"> |
1095 |
|
1096 |
Liver and kidney of swine 14 days |
1097 |
|
1098 |
</p> |
1099 |
</div> |
1100 |
|
1101 |
|
1102 |
|
1103 |
|
1104 |
|
1105 |
|
1106 |
|
1107 |
|
1108 |
|
1109 |
|
1110 |
|
1111 |
|
1112 |
<div align="justify"> |
1113 |
<p style="text-align: justify;"> |
1114 |
|
1115 |
|
1116 |
|
1117 |
</p> |
1118 |
</div> |
1119 |
|
1120 |
|
1121 |
|
1122 |
|
1123 |
|
1124 |
|
1125 |
|
1126 |
|
1127 |
|
1128 |
|
1129 |
|
1130 |
|
1131 |
<div align="justify"> |
1132 |
<p style="text-align: justify;"> |
1133 |
|
1134 |
<b><i>Storage</i></b> |
1135 |
|
1136 |
</p> |
1137 |
</div> |
1138 |
|
1139 |
|
1140 |
|
1141 |
|
1142 |
|
1143 |
|
1144 |
|
1145 |
|
1146 |
|
1147 |
|
1148 |
|
1149 |
|
1150 |
<div align="justify"> |
1151 |
<p style="text-align: justify;"> |
1152 |
|
1153 |
Store in a dry place at room temperature (up to 25°C). Keep away from children. |
1154 |
|
1155 |
</p> |
1156 |
</div> |
1157 |
|
1158 |
|
1159 |
|
1160 |
|
1161 |
|
1162 |
|
1163 |
|
1164 |
|
1165 |
|
1166 |
|
1167 |
|
1168 |
|
1169 |
<div align="justify"> |
1170 |
<p style="text-align: justify;"> |
1171 |
|
1172 |
|
1173 |
|
1174 |
</p> |
1175 |
</div> |
1176 |
|
1177 |
|
1178 |
|
1179 |
|
1180 |
|
1181 |
|
1182 |
|
1183 |
|
1184 |
|
1185 |
|
1186 |
|
1187 |
|
1188 |
<div align="justify"> |
1189 |
<p style="text-align: justify;"> |
1190 |
|
1191 |
Nutricin Sulfa<b><sup>®</sup></b>140 mixed with feed or pelleted maintains its potency over 3 months. |
1192 |
|
1193 |
</p> |
1194 |
</div> |
1195 |
|
1196 |
|
1197 |
|
1198 |
|
1199 |
|
1200 |
|
1201 |
|
1202 |
|
1203 |
|
1204 |
|
1205 |
|
1206 |
|
1207 |
<div align="justify"> |
1208 |
<p style="text-align: justify;"> |
1209 |
|
1210 |
|
1211 |
|
1212 |
</p> |
1213 |
</div> |
1214 |
|
1215 |
|
1216 |
|
1217 |
|
1218 |
|
1219 |
|
1220 |
|
1221 |
|
1222 |
|
1223 |
|
1224 |
|
1225 |
|
1226 |
<div align="justify"> |
1227 |
<p style="text-align: justify;"> |
1228 |
|
1229 |
<b><i>Shelf life</i></b> |
1230 |
|
1231 |
</p> |
1232 |
</div> |
1233 |
|
1234 |
|
1235 |
|
1236 |
|
1237 |
|
1238 |
|
1239 |
|
1240 |
|
1241 |
|
1242 |
|
1243 |
|
1244 |
|
1245 |
<div align="justify"> |
1246 |
<p style="text-align: justify;"> |
1247 |
|
1248 |
Denoted on the packaging (2 years in the original pack). |
1249 |
|
1250 |
</p> |
1251 |
</div> |
1252 |
|
1253 |
|
1254 |
|
1255 |
|
1256 |
|
1257 |
|
1258 |
|
1259 |
|
1260 |
|
1261 |
|
1262 |
|
1263 |
|
1264 |
<div align="justify"> |
1265 |
<p style="text-align: justify;"> |
1266 |
|
1267 |
<b></b> |
1268 |
|
1269 |
</p> |
1270 |
</div> |
1271 |
|
1272 |
|
1273 |
|
1274 |
|
1275 |
|
1276 |
|
1277 |
|
1278 |
|
1279 |
|
1280 |
|
1281 |
|
1282 |
|
1283 |
<div align="justify"> |
1284 |
<p style="text-align: justify;"> |
1285 |
|
1286 |
<b><i>Legal category</i></b><b></b> |
1287 |
|
1288 |
</p> |
1289 |
</div> |
1290 |
|
1291 |
|
1292 |
|
1293 |
|
1294 |
|
1295 |
|
1296 |
|
1297 |
|
1298 |
|
1299 |
|
1300 |
|
1301 |
|
1302 |
<div align="justify"> |
1303 |
<p style="text-align: justify;"> |
1304 |
|
1305 |
On prescription only or at the written veterinarian's request to prepare. |
1306 |
|
1307 |
</p> |
1308 |
</div> |
1309 |
|
1310 |
|
1311 |
|
1312 |
|
1313 |
|
1314 |
|
1315 |
|
1316 |
|
1317 |
|
1318 |
|
1319 |
|
1320 |
|
1321 |
<div align="justify"> |
1322 |
<p style="text-align: justify;"> |
1323 |
|
1324 |
|
1325 |
|
1326 |
</p> |
1327 |
</div> |
1328 |
|
1329 |
|
1330 |
|
1331 |
|
1332 |
|
1333 |
|
1334 |
|
1335 |
|
1336 |
|
1337 |
|
1338 |
|
1339 |
|
1340 |
<div align="justify"> |
1341 |
<p style="text-align: justify;"> |
1342 |
|
1343 |
<b><i>Supply</i></b> |
1344 |
|
1345 |
</p> |
1346 |
</div> |
1347 |
|
1348 |
|
1349 |
|
1350 |
|
1351 |
|
1352 |
|
1353 |
|
1354 |
|
1355 |
|
1356 |
|
1357 |
|
1358 |
|
1359 |
<div align="justify"> |
1360 |
<p style="text-align: justify;"> |
1361 |
|
1362 |
200 g, 1000 g and 25 kg bags. |
1363 |
|
1364 |
</p> |
1365 |
</div> |
1366 |
|
1367 |
|
1368 |
|
1369 |
|
1370 |
|
1371 |
|
1372 |
|
1373 |
|
1374 |
|
1375 |
|
1376 |
|
1377 |
|
1378 |
<div align="justify"> |
1379 |
<p style="text-align: justify;"> |
1380 |
|
1381 |
<b></b> |
1382 |
|
1383 |
</p> |
1384 |
</div> |
1385 |
|
1386 |
|
1387 |
|
1388 |
|
1389 |
|
1390 |
|
1391 |
|
1392 |
|
1393 |
|
1394 |
|
1395 |
|
1396 |
|
1397 |
<div align="justify"> |
1398 |
<p style="text-align: justify;"> |
1399 |
|
1400 |
<b><i>Manufacturer</i></b><b></b> |
1401 |
|
1402 |
</p> |
1403 |
</div> |
1404 |
|
1405 |
|
1406 |
|
1407 |
|
1408 |
|
1409 |
|
1410 |
|
1411 |
|
1412 |
|
1413 |
|
1414 |
|
1415 |
|
1416 |
<div align="justify"> |
1417 |
<p style="text-align: justify;"> |
1418 |
|
1419 |
VETERINA Animal Health Ltd., Croatia<b></b> |
1420 |
|
1421 |
</p> |
1422 |
</div> |
1423 |
|
1424 |
|
1425 |
|
1426 |
|
1427 |
|
1428 |
|
1429 |
|
1430 |
|
1431 |
|
1432 |
|
1433 |
|
1434 |
|
1435 |
<div align="justify"> |
1436 |
<p style="text-align: justify;"> |
1437 |
|
1438 |
|
1439 |
|
1440 |
</p> |
1441 |
</div> |
1442 |
|
1443 |
|
1444 |
|
1445 |
|
1446 |
|
1447 |
|
1448 |
|
1449 |
|
1450 |
|
1451 |
|
1452 |
|
1453 |
|
1454 |
<div align="left"> |
1455 |
<p style="text-align: left;"> |
1456 |
|
1457 |
|
1458 |
|
1459 |
</p> |
1460 |
</div> |
1461 |
|
1462 |
|
1463 |
|
1464 |
|
1465 |
|
1466 |
|
1467 |
|
1468 |
<!--Section Ends--> |
1469 |
|
1470 |
|
1471 |
|
1472 |
|
1473 |
|
1474 |
|
1475 |
|
1476 |
|