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1 dpavlin 1.1 <p align="left"><font size="4" color="#FF9933"><b><font color="#000000" size="3">Development
2     of NCE`s</font></b></font></p>
3     <table width="90%" border="0" cellspacing="0" cellpadding="0" align="center">
4     <tr>
5     <td height="10" width="19%">
6     <div align="center"><b>PROJECT</b></div>
7     </td>
8     <td height="10" width="26%">
9     <div align="center"><b>INDICATION</b></div>
10     </td>
11     <td height="10" width="24%">
12     <div align="center"><b>STATUS</b></div>
13     </td>
14     <td height="10" width="31%">
15     <div align="center"><b>MARKET POTENTIAL </b></div>
16     </td>
17     </tr>
18     </table>
19     <table width="90%" border="1" cellspacing="0" cellpadding="0" align="center">
20     <tr>
21     <td width="19%">
22     <div align="center">PLD - 116</div>
23     </td>
24     <td width="26%">
25     <div align="center">Inflammatory Bowel Disease (IBD)</div>
26     </td>
27     <td width="24%">
28     <div align="center">Preclinical Development</div>
29     </td>
30     <td width="31%">
31     <div align="center">US$ 600 m. to US$ 1bn</div>
32     </td>
33     </tr>
34     <tr>
35     <td width="19%">
36     <div align="center">PLD - 117</div>
37     </td>
38     <td width="26%">
39     <div align="center">Oncology<br>
40     Hematology</div>
41     </td>
42     <td width="24%">
43     <div align="center">Preclinical Development</div>
44     </td>
45     <td width="31%">
46     <div align="center">US$ 600-900 m.</div>
47     </td>
48     </tr>
49     <tr>
50     <td width="19%">
51     <div align="center">PLD - 118</div>
52     </td>
53     <td width="26%">
54     <div align="center">Anti-fungal</div>
55     </td>
56     <td width="24%">
57     <div align="center">Preclinical Development</div>
58     </td>
59     <td width="31%">
60     <div align="center">US$ 600-800 m.</div>
61     </td>
62     </tr>
63     <tr>
64     <td width="19%">
65     <div align="center">PLR - 1</div>
66     </td>
67     <td width="26%">
68     <div align="center">Anti-infective</div>
69     </td>
70     <td width="24%">
71     <div align="center">Discovery</div>
72     </td>
73     <td width="31%">
74     <div align="center">~ US$ 1 bn</div>
75     </td>
76     </tr>
77     <tr>
78     <td width="19%">
79     <div align="center">PLR - 13</div>
80     </td>
81     <td width="26%">
82     <div align="center">Inflammation<br>
83     Asthma</div>
84     </td>
85     <td width="24%">
86     <div align="center">Discovery</div>
87     </td>
88     <td width="31%">
89     <div align="center">~ US$ 500 m.</div>
90     </td>
91     </tr>
92     <tr>
93     <td width="19%">
94     <div align="center">PLR - 9</div>
95     </td>
96     <td width="26%">
97     <div align="center">Anti-infective</div>
98     </td>
99     <td width="24%">
100     <div align="center">Discovery</div>
101     </td>
102     <td width="31%">
103     <div align="center">~ US$ 1 bn</div>
104     </td>
105     </tr>
106     <tr>
107     <td width="19%">
108     <div align="center">PLR - 14</div>
109     </td>
110     <td width="26%">
111     <div align="center">Inflammation<br>
112     RA, IBD</div>
113     </td>
114     <td width="24%">
115     <div align="center">Discovery</div>
116     </td>
117     <td width="31%">
118     <div align="center">~ US$ 1 bn </div>
119     </td>
120     </tr>
121     </table>
122     <table width="100%" border="0" cellspacing="3" cellpadding="0">
123     <tr>
124     <td>
125     <hr size="1" width="100%">
126     </td>
127     </tr>
128     </table>
129     <p><b>Development of Generics</b></p>
130     <table width="90%" align="center" border="0" cellspacing="0" cellpadding="0">
131     <tr>
132     <td width="25%" height="35">
133     <div align="center"><b>GENERIC PRODUCT</b></div>
134     </td>
135     <td width="23%" height="35">
136     <div align="center"><b>FIRST REGISTRATION EXPECTED</b> </div>
137     </td>
138     <td width="25%" height="35">
139     <div align="center"><b>GENERIC PRODUCT</b></div>
140     </td>
141     <td width="27%" height="35">
142     <div align="center"><b>FIRST REGISTRATION EXPECTED</b></div>
143     </td>
144     </tr>
145     <tr>
146     <td colspan="4">
147     <table width="100%" border="1" cellspacing="0" cellpadding="0">
148     <tr>
149     <td width="25%">Simvastatin</td>
150     <td width="23%">
151     <div align="center">2001</div>
152     </td>
153     <td width="25%">Losartan</td>
154     <td width="27%">
155     <div align="center">2002</div>
156     </td>
157     </tr>
158     <tr>
159     <td width="25%">Loratadin</td>
160     <td width="23%">
161     <div align="center">2001</div>
162     </td>
163     <td width="25%">Carvedilol</td>
164     <td width="27%">
165     <div align="center">2002</div>
166     </td>
167     </tr>
168     <tr>
169     <td width="25%">Erythropoietin</td>
170     <td width="23%">
171     <div align="center">2001</div>
172     </td>
173     <td width="25%">Bisoprolol</td>
174     <td width="27%">
175     <div align="center">2003</div>
176     </td>
177     </tr>
178     <tr>
179     <td width="25%">Warfarin</td>
180     <td width="23%">
181     <div align="center">2001</div>
182     </td>
183     <td width="25%">Losartan+HCTZ</td>
184     <td width="27%">
185     <div align="center">2003</div>
186     </td>
187     </tr>
188     <tr>
189     <td width="25%">Diklofenac</td>
190     <td width="23%">
191     <div align="center">2001</div>
192     </td>
193     <td width="25%">Clarithromycin</td>
194     <td width="27%">
195     <div align="center">2003</div>
196     </td>
197     </tr>
198     <tr>
199     <td width="25%">Ca folinat</td>
200     <td width="23%">
201     <div align="center">2001</div>
202     </td>
203     <td width="25%">Venlafaxine</td>
204     <td width="27%">
205     <div align="center">2003</div>
206     </td>
207     </tr>
208     <tr>
209     <td width="25%">Ondansetron</td>
210     <td width="23%">
211     <div align="center">2002</div>
212     </td>
213     <td width="25%">Interferon alpha</td>
214     <td width="27%">
215     <div align="center">2003</div>
216     </td>
217     </tr>
218     <tr>
219     <td width="25%">Torasemid</td>
220     <td width="23%">
221     <div align="center">2002</div>
222     </td>
223     <td width="25%">Paroxetin</td>
224     <td width="27%">
225     <div align="center">2003</div>
226     </td>
227     </tr>
228     <tr>
229     <td width="25%">Amlodipin</td>
230     <td width="23%">
231     <div align="center">2002</div>
232     </td>
233     <td width="25%">HGH</td>
234     <td width="27%">
235     <div align="center">2003</div>
236     </td>
237     </tr>
238     <tr>
239     <td width="25%">Risperidone</td>
240     <td width="23%">
241     <div align="center">2002</div>
242     </td>
243     <td width="25%">Meloxicam</td>
244     <td width="27%">
245     <div align="center">2003</div>
246     </td>
247     </tr>
248     <tr>
249     <td width="25%">Alendronate</td>
250     <td width="23%">
251     <div align="center">2002</div>
252     </td>
253     <td width="25%">Interferon beta</td>
254     <td width="27%">
255     <div align="center">2004</div>
256     </td>
257     </tr>
258     <tr>
259     <td width="25%">Ciprofloxacin</td>
260     <td width="23%">
261     <div align="center">2002</div>
262     </td>
263     <td width="25%">Indapamide</td>
264     <td width="27%">
265     <div align="center">2004</div>
266     </td>
267     </tr>
268     <tr>
269     <td width="25%">Mesalazin</td>
270     <td width="23%">
271     <div align="center">2002</div>
272     </td>
273     <td width="25%">Cytostatics (9)</td>
274     <td width="27%">
275     <div align="center">2001-2003</div>
276     </td>
277     </tr>
278     <tr>
279     <td width="25%">G-CSF </td>
280     <td width="23%">
281     <div align="center">2002</div>
282     </td>
283     <td width="25%">OTC products (9)</td>
284     <td width="27%">
285     <div align="center">2001-2003</div>
286     </td>
287     </tr>
288     </table>
289     </td>
290     </tr>
291     </table>
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